Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95602
Title: Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles for Oral Administration by Spray-Cooling
Authors: Favaro-Trindade, Carmen S.
Matos Junior, Fernando E. de
Okuro, Paula K.
Dias-Ferreira, João
Cano, Amanda
Severino, Patricia
Zielińska, Aleksandra
Souto, Eliana B. 
Keywords: Spray chilling; Congealing spray; Spray cooling; Lipid nanoparticles; Oral drug delivery
Issue Date: 2021
Publisher: MDPI
Project: UIDB/04469/2020/PT 
Serial title, monograph or event: Pharmaceutics
Volume: 13
Issue: 8
Abstract: Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solvents (mostly associated to toxicological risk), and it can be applied for lipid raw materials as excipients of oral pharmaceutical formulations. The objective of this work was to revise and discuss the advances of spray cooling technology, with a greater emphasis on the development of lipid micro/nanoparticles to the load of active pharmaceutical ingredients for oral administration.
URI: http://hdl.handle.net/10316/95602
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics13081186
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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