Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/95122
Title: The role of mitochondria-associated membranes in cellular homeostasis and diseases
Authors: Perrone, Mariasole
Caroccia, Natascia
Genovese, Ilaria
Missiroli, Sonia
Modesti, Lorenzo
Pedriali, Gaia
Vezzani, Bianca
Vitto, Veronica Angela Maria
Antenori, Michele
Lebiedzinska-Arciszewska, Magdalena
Wieckowski, Mariusz R. 
Giorgi, Carlotta
Pinton, Paolo
Keywords: Autophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROS
Issue Date: Jan-2020
Publisher: Elsevier
Project: Italian Association for Cancer Research (AIRC, IG-18624) 
Telethon (GGP11139B) 
University of Ferrara 
Italian Association for Cancer Research (AIRC: IG-19803) 
Italian Ministry of Health (GR-2013-02356747) 
Fondazione Cariplo grant 
Polish National Science Centre grant (UMO-2018/29/B/NZ1/00589) 
Polish National Science Centre grant UMO-2015/17/D/NZ1/00030 
info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS 
Serial title, monograph or event: Biology of the Endoplasmic Reticulum
Volume: 350
Abstract: Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases.
URI: https://hdl.handle.net/10316/95122
ISBN: 9780128197448
DOI: 10.1016/bs.ircmb.2019.11.002
Rights: embargoedAccess
Appears in Collections:I&D CNC - Capítulos (ou partes) de Livros

Files in This Item:
File Description SizeFormat
Mitochondria associated membranes_IRCMB_reviewed.pdf626.06 kBAdobe PDFView/Open
Show full item record

SCOPUSTM   
Citations

88
checked on Sep 9, 2024

WEB OF SCIENCETM
Citations

74
checked on Sep 2, 2024

Page view(s)

250
checked on Oct 9, 2024

Download(s)

959
checked on Oct 9, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons