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https://hdl.handle.net/10316/95122
Title: | The role of mitochondria-associated membranes in cellular homeostasis and diseases | Authors: | Perrone, Mariasole Caroccia, Natascia Genovese, Ilaria Missiroli, Sonia Modesti, Lorenzo Pedriali, Gaia Vezzani, Bianca Vitto, Veronica Angela Maria Antenori, Michele Lebiedzinska-Arciszewska, Magdalena Wieckowski, Mariusz R. Giorgi, Carlotta Pinton, Paolo |
Keywords: | Autophagy; Calcium transfer apoptosis; Cancer; Diabetes; Inflammation and antiviral response; Lipid trafficking and metabolism; Mitochondrial dynamics; Neurodegenerative diseases; ROS | Issue Date: | Jan-2020 | Publisher: | Elsevier | Project: | Italian Association for Cancer Research (AIRC, IG-18624) Telethon (GGP11139B) University of Ferrara Italian Association for Cancer Research (AIRC: IG-19803) Italian Ministry of Health (GR-2013-02356747) Fondazione Cariplo grant Polish National Science Centre grant (UMO-2018/29/B/NZ1/00589) Polish National Science Centre grant UMO-2015/17/D/NZ1/00030 info:eu-repo/grantAgreement/H2020/722619/EU/MarieSkłodowska-Curie/FOIEGRAS |
Serial title, monograph or event: | Biology of the Endoplasmic Reticulum | Volume: | 350 | Abstract: | Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell physiology regulating several signal transduction pathways. They continuously communicate exchanging messages in their contact sites called MAMs (mitochondria-associated membranes). MAMs are specific microdomains acting as a platform for the sorting of vital and dangerous signals. In recent years increasing evidence reported that multiple scaffold proteins and regulatory factors localize to this subcellular fraction suggesting MAMs as hotspot signaling domains. In this review we describe the current knowledge about MAMs' dynamics and processes, which provided new correlations between MAMs' dysfunctions and human diseases. In fact, MAMs machinery is strictly connected with several pathologies, like neurodegeneration, diabetes and mainly cancer. These pathological events are characterized by alterations in the normal communication between ER and mitochondria, leading to deep metabolic defects that contribute to the progression of the diseases. | URI: | https://hdl.handle.net/10316/95122 | ISBN: | 9780128197448 | DOI: | 10.1016/bs.ircmb.2019.11.002 | Rights: | embargoedAccess |
Appears in Collections: | I&D CNC - Capítulos (ou partes) de Livros |
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Mitochondria associated membranes_IRCMB_reviewed.pdf | 626.06 kB | Adobe PDF | View/Open |
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