Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/95089
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Marques-Aleixo, Inês | - |
dc.contributor.author | Beleza, Jorge | - |
dc.contributor.author | Sampaio, Arnaldina | - |
dc.contributor.author | Stevanović, Jelena | - |
dc.contributor.author | Coxito, Pedro | - |
dc.contributor.author | Gonçalves, Inês | - |
dc.contributor.author | Ascensão, António | - |
dc.contributor.author | Magalhães, José | - |
dc.date.accessioned | 2021-06-21T14:30:35Z | - |
dc.date.available | 2021-06-21T14:30:35Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1523-0864 | pt |
dc.identifier.issn | 1557-7716 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/95089 | - |
dc.description.abstract | Significance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs. | pt |
dc.language.iso | eng | pt |
dc.relation | FCT/UID/DTP/00617/2019 | pt |
dc.relation | POCI-01-0145-FEDER-016690-PTDC/DTP-702DES/7087/2014 | pt |
dc.relation | POCI-01-0145-FEDER-016657–PTDC/DTP-DES/1082/2014 | pt |
dc.relation | JB SFRH/BD/129645/2017. | pt |
dc.relation | Marie Skłodowska-Curie | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle | pt |
dc.title | Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases | pt |
dc.type | article | - |
degois.publication.firstPage | 674-693 | pt |
degois.publication.lastPage | 693 | pt |
degois.publication.issue | 8 | pt |
degois.publication.title | Antioxidants & Redox Signaling | pt |
dc.relation.publisherversion | https://www.liebertpub.com/doi/10.1089/ars.2020.8075?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1089/ars.2020.8075 | pt |
degois.publication.volume | 34 | pt |
dc.date.embargo | 2022-01-01 | * |
uc.date.periodoEmbargo | 365 | pt |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Marques-Aleixo et al ARS_2019.pdf | 666.77 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
31
checked on Sep 9, 2024
WEB OF SCIENCETM
Citations
31
checked on Sep 2, 2024
Page view(s)
202
checked on Oct 16, 2024
Download(s)
450
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License