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https://hdl.handle.net/10316/95079| Title: | Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease | Authors: | Majdi, Amine Aoudjehane, Lynda Ratziu, Vlad Islam, Tawhidul Afonso, Marta B Conti, Filomena Mestiri, Taïeb Lagouge, Marie Foufelle, Fabienne Ballenghien, Florine Ledent, Tatiana Moldes, Marthe Cadoret, Axelle Fouassier, Laura Delaunay, Jean-Louis Aït-Slimane, Tounsia Courtois, Gilles Fève, Bruno Scatton, Olivier Prip-Buus, Carina Rodrigues, Cecília M P Housset, Chantal Gautheron, Jérémie |
Keywords: | MLKL; NAFLD; NASH; Necroptosis; RIPK1; Steatosis | Issue Date: | Apr-2020 | Publisher: | Elsevier | Project: | Fondation pour la Recherche Médicale (FRM – ARF20170938613) Institute of Cardiometabolism and Nutrition (ICAN – PAP17NECJG) Société Francophone du Diabète (SFD – R19114DD) Mairie de Paris (Emergences – R18139DD) Ministère de l'Enseignement Supérieur et de la Recherche (MESR) Fundação para a Ciência e a Tecnologia (PTDC/MED-FAR/ 29097/2017) Marie Sklodowska-Curie 722619 grant |
Serial title, monograph or event: | Journal of Hepatology | Volume: | 72 | Issue: | 4 | Abstract: | In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and markers of activity in NAFLD. | URI: | https://hdl.handle.net/10316/95079 | ISSN: | 01688278 | DOI: | 10.1016/j.jhep.2019.11.008 | Rights: | embargoedAccess |
| Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Revised_Manuscript_JHEPAT-D-19-00929.pdf | 306.22 kB | Adobe PDF | View/Open | |
| Figures.pdf | 694.43 kB | Adobe PDF | View/Open |
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