Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/92840
DC FieldValueLanguage
dc.contributor.authorvan Asselen, Marieke-
dc.contributor.authorAlmeida, Inês-
dc.contributor.authorJúlio, Filipa-
dc.contributor.authorJanuário, Cristina-
dc.contributor.authorCampos, Elzbieta Bobrowicz-
dc.contributor.authorSimões, Mário-
dc.contributor.authorCastelo-Branco, Miguel-
dc.date.accessioned2021-02-02T10:14:07Z-
dc.date.available2021-02-02T10:14:07Z-
dc.date.issued2012-07-
dc.identifier.issn1355-6177pt
dc.identifier.issn1469-7661pt
dc.identifier.urihttps://hdl.handle.net/10316/92840-
dc.description.abstractHuntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.pt
dc.language.isoengpt
dc.publisherCambridge University Presspt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject.meshAdultpt
dc.subject.meshAttentionpt
dc.subject.meshCuespt
dc.subject.meshDisease Progressionpt
dc.subject.meshFemalept
dc.subject.meshHumanspt
dc.subject.meshHuntington Diseasept
dc.subject.meshMalept
dc.subject.meshMemorypt
dc.subject.meshMiddle Agedpt
dc.subject.meshNeuropsychological Testspt
dc.subject.meshReaction Timept
dc.subject.meshRecognition, Psychologypt
dc.subject.meshLearningpt
dc.titleImplicit contextual learning in prodromal and early stage Huntington's disease patientspt
dc.typearticle-
degois.publication.firstPage689pt
degois.publication.lastPage696pt
degois.publication.issue4pt
degois.publication.titleJournal of the International Neuropsychological Societypt
dc.relation.publisherversionhttps://www.cambridge.org/core/journals/journal-of-the-international-neuropsychological-society/article/implicit-contextual-learning-in-prodromal-and-early-stage-huntingtons-disease-patients/0B1C4B959F0E8B22C118FD5F39C556C6#articlept
dc.peerreviewedyespt
dc.identifier.doi10.1017/S1355617712000288pt
degois.publication.volume18pt
dc.date.embargo2012-07-01*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCIBIT - Coimbra Institute for Biomedical Imaging and Translational Research-
crisitem.author.researchunitCINEICC – Center for Research in Neuropsychology and Cognitive and Behavioural Intervention-
crisitem.author.researchunitCIBIT - Coimbra Institute for Biomedical Imaging and Translational Research-
crisitem.author.orcid0000-0002-2279-2032-
crisitem.author.orcid0000-0003-0230-3075-
crisitem.author.orcid0000-0001-5402-3978-
crisitem.author.orcid0000-0002-1311-1338-
crisitem.author.orcid0000-0003-4364-6373-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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