Please use this identifier to cite or link to this item:
Title: The role of innate immunity in spontaneous preterm labor: A systematic review
Authors: Areia, Ana Luísa 
Moura, Paulo 
Mota-Pinto, Anabela 
Keywords: Imunidade inata; Parto pré-termo; Innate immunity; Preterm birth
Issue Date: Nov-2019
Publisher: Elsevier
Serial title, monograph or event: Journal of Reproductive Immunology
Volume: 136
Abstract: Background: Immunoinflammatory response by innate immunity components is a field with increasing interest in understanding the mechanisms behind preterm labor (PTL). Objectives: Systematic review of the role of innate immunity in spontaneous PTL. Study design: PubMed, Scopus, and Web of Science were searched using pregnancy AND innate OR toll-like OR natural-killer OR dendritic AND delivery OR premature OR rupture of membranes. Main outcome measures: All article titles and abstracts were evaluated by two individuals, based in strict predefined inclusion criteria. For relevant studies, title, abstract, and full text were assessed to identify PTL and innate immunity studies, excluding multiple pregnancies, cervical insufficiency and indicated PTL. Results: From 894 articles evaluated, 101 full texts articles were assessed independently. For this systematic review 44 studies were finally included. Toll-like receptors 2 and 4 mediated immune dysfunction and inflammation can result in PTL. Moreover, PTL is linked to high levels of CD14+ monocytes; neutrophils seem important in inflammation-associated PTL and in pathological preterm premature rupture of membranes. Besides, decidual natural-killer cells and premature activation of dendritic cells may also participate in the etiology of PTL. Finally, dysregulation of maternal complement might increase the risk of PTL, characterized by high levels of innate lymphoid cells 2 and 3. Conclusions: Further research is warranted to ascertain the precise role of innate immunity in PTL. Nonetheless, our results indicate that Toll-like receptors, monocytes, natural-killer cells, dendritic cells and complement have significant roles in PTL.
ISSN: 0165-0378
DOI: 10.1016/j.jri.2019.102616
Rights: closedAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat Login
The_role_of_innate_immunity_in_spontaneous_preterm_labor(JRI19).pdf838.25 kBAdobe PDF    Request a copy
Show full item record


checked on Feb 2, 2021

Page view(s)

checked on Feb 25, 2021


checked on Feb 25, 2021

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.