Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/92619
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rebelo, Diliana | - |
dc.contributor.author | Oliveira, Francisco | - |
dc.contributor.author | Abrunhosa, Antero | - |
dc.contributor.author | Januário, Cristina | - |
dc.contributor.author | Lemos, João | - |
dc.contributor.author | Castelo-Branco, Miguel | - |
dc.date.accessioned | 2021-01-20T15:34:47Z | - |
dc.date.available | 2021-01-20T15:34:47Z | - |
dc.date.issued | 2021-01-19 | - |
dc.identifier.issn | 0027-8424 | pt |
dc.identifier.issn | 1091-6490 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/92619 | - |
dc.description.abstract | The link between synaptic plasticity and reorganization of brain activity in health and disease remains a scientific challenge. We examined this question in Parkinson's disease (PD) where functional up-regulation of postsynaptic D2 receptors has been documented while its significance at the neural activity level has never been identified. We investigated cortico-subcortical plasticity in PD using the oculomotor system as a model to study reorganization of dopaminergic networks. This model is ideal because this system reorganizes due to frontal-to-parietal shifts in blood oxygen level-dependent (BOLD) activity. We tested the prediction that functional activation plasticity is associated with postsynaptic dopaminergic modifications by combining positron emission tomography/functional magnetic resonance imaging to investigate striatal postsynaptic reorganization of dopamine D2 receptors (using 11C-raclopride) and neural activation in PD. We used covariance (connectivity) statistics at molecular and functional levels to probe striato-cortical reorganization in PD in on/off medication states to show that functional and molecular forms of reorganization are related. D2 binding across regions defined by prosaccades showed increased molecular connectivity between both caudate/putamen and hyperactive parietal eye fields in PD in contrast with frontal eye fields in controls, in line with the shift model. Concerning antisaccades, parietal-striatal connectivity dominated in again in PD, unlike frontal regions. Concerning molecular-BOLD covariance, a striking sign reversal was observed: PD patients showed negative frontal-putamen functional-molecular associations, consistent with the reorganization shift, in contrast with the positive correlations observed in controls. Follow-up analysis in off-medication PD patients confirmed the negative BOLD-molecular correlation. These results provide a link among BOLD responses, striato-cortical synaptic reorganization, and neural plasticity in PD. | pt |
dc.language.iso | eng | pt |
dc.publisher | National Academy of Sciences | pt |
dc.relation | FCT/UID/4950/201 | pt |
dc.relation | PAC/MEDPERSYST-16428 | pt |
dc.relation | CENTRO-01-0145-FEDER-000016 | pt |
dc.relation | Bial Foundation 252/18 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Functional connectivity | pt |
dc.subject | Functional magnetic resonance imaging | pt |
dc.subject.mesh | Molecular imaging | pt |
dc.subject.mesh | Positron emission tomography | pt |
dc.title | A link between synaptic plasticity and reorganization of brain activity in Parkinson's disease | pt |
dc.type | article | - |
degois.publication.firstPage | e2013962118 | pt |
degois.publication.issue | 3 | pt |
degois.publication.title | PNAS - Proceedings of the National Academy of Sciences of the United States of America | pt |
dc.relation.publisherversion | https://www.pnas.org/content/118/3/e2013962118 | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1073/pnas.2013962118 | pt |
degois.publication.volume | 118 | pt |
dc.date.embargo | 2021-01-19 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | ICNAS - Institute for Nuclear Sciences Applied to Health | - |
crisitem.author.researchunit | CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research | - |
crisitem.author.orcid | 0000-0003-0279-0221 | - |
crisitem.author.orcid | 0000-0001-9468-8894 | - |
crisitem.author.orcid | 0000-0002-4145-854X | - |
crisitem.author.orcid | 0000-0001-5402-3978 | - |
crisitem.author.orcid | 0000-0002-9128-7064 | - |
crisitem.author.orcid | 0000-0003-4364-6373 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
A link between synaptic plasticity and reorganization.pdf | 1.12 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Nov 9, 2022
WEB OF SCIENCETM
Citations
7
checked on May 2, 2024
Page view(s)
288
checked on May 7, 2024
Download(s)
210
checked on May 7, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License