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http://hdl.handle.net/10316/92397| Title: | Stem cells as vehicles and targets of nanoparticles | Authors: | Pinho, Sónia Macedo, Maria H Rebelo, Catarina Araujo Gomes Sarmento, Bruno Ferreira, Lino |
Issue Date: | 2018 | Publisher: | Elsevier | Project: | This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Inovação in the framework of the projects "Institute for Research 15 and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274 to BS); EC (ERC project nº 307384, “Nanotrigger” and ERA-Chair project nº 669088, ERA@UC, both to LF). SP, MHM and CR would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal, for financial support (SFRH/BPD/96048/2013; SFRH/BD/131587/2017; SFRH/BD/52337/2013). | Serial title, monograph or event: | Drug Discovery Today | Volume: | 23 | Issue: | 5 | Abstract: | Modulation of endogenous adult stem cell niches represents a promising strategy for regeneration of tissues and to correct cell abnormalities, including cancer. Recent advances show the possibility to target endogenous stem cells or their progenies by using nanoparticles conjugated with specific biomolecules. In addition, the targeting of the stem cell niche can be accomplished by using stem cells loaded with nanoparticles. This review examines principles for the targeting of endogenous stem cells as well as factors for the modulation of stem cells. | URI: | http://hdl.handle.net/10316/92397 | ISSN: | 13596446 | DOI: | 10.1016/j.drudis.2018.01.030 | Rights: | openAccess |
| Appears in Collections: | UC Bibliotecas - Artigos em Revistas Internacionais |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Pinho et al. Drug Discovery.pdf | 1.72 MB | Adobe PDF | View/Open |
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