Please use this identifier to cite or link to this item:
Title: Can immunity during pregnancy influence SARS-CoV-2 infection? – A systematic review
Authors: Areia, Ana Luísa Fialho Amaral de 
Pinto, Anabela Mota 
Keywords: Gravidez/Pregnancy; COVID-19; SARS-CoV-2; Imunidade/Immunity
Issue Date: 2020
Publisher: Elsevier
Serial title, monograph or event: Journal of Reproductive Immunology
Issue: 142
Abstract: Background: During pregnancy, the maternal immune system must create and sustain tolerance to the allogeneic fetus while maintaining the ability to protect against microbial assaults. Objectives: Ascertain the immunological differences in immune cells of pregnant women that may influence SARS-CoV-2 infection. Study design: Systematic review conducted in accordance with PRISMA guidelines and registered within PROSPERO CRD42020189735. A systematic search was undertaken across ISI, PubMed, Scopus, Embase, Cochrane Library and clinical from January 2019 up until June 2020. Eligibility criteria included COVID-19 infection, pregnancy, and availability of immune characteristics for the pregnant women. Two authors independently screened for the suitability of inclusion. Main outcome measures: Information was manually extracted from full-text articles and efforts were made to identify overlapping data. Variables extracted and analysed included the quantification of white blood cells (WBC), lymphocytes, and C-reactive protein (CRP). Results: The literature search yielded 162 studies, of which 11 were considered appropriate for selection. Only four were used in this systematic review. Our research showed that pregnant women with COVID-19 only differ from other pregnant women in their lower WBC count. The proportion of reduced lymphocyte cases is similar in both groups, as is the case of Creactive protein levels. Conclusions: In line with previous coronavirus infections, severe maternal morbidity and perinatal death with COVID-19 infection were more likely to be expected in pregnancy. Our research showed that pregnant women with COVID-19 in terms of immunity only differ from other pregnant women in their lower WBC count.
ISSN: 01650378
DOI: 10.1016/j.jri.2020.103215
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
Can immunity during pregnancy influence SARS-CoV-2 infection?.pdf495.93 kBAdobe PDFView/Open
Show full item record

Page view(s)

checked on Feb 25, 2021


checked on Feb 25, 2021

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.