Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/91152
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Félix, Ana Rita G. | - |
dc.contributor.author | Simões, Pedro R. D. | - |
dc.contributor.author | Sousa, Francisco J. P. M. | - |
dc.contributor.author | Serra, Maria Elisa Silva | - |
dc.contributor.author | Murtinho, Dina | - |
dc.date.accessioned | 2020-10-10T11:33:38Z | - |
dc.date.available | 2020-10-10T11:33:38Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 15701786 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/91152 | - |
dc.description.abstract | Several novel chiral organocatalysts derived from thiazolidines containing amide and thioureia functionalities were synthesized in good yields. These organocatalysts were tested in the asymmetric aldol reaction of acetone with p-nitrobenzaldehyde. Reaction parameters such as reaction time, catalyst loading and solvent were optimized. Products with conversions up to 84% and enantiomeric ratios (er) up to 84.5:15.5 (R:S) were obtained. The effect of several chiral and non-chiral additives on the reactivity and selectivity of the reaction was also evaluated. The reaction was extended to other aromatic aldehydes with the best organocatalyst and when p-bromobenzaldehyde was used, an er of 94.5:5.5 (R:S) was obtained. | pt |
dc.language.iso | eng | pt |
dc.publisher | Bentham Science Publishers | pt |
dc.relation | info:eu-repo/grantAgreement/FCT/00313/2019/PT | pt |
dc.rights | embargoedAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Thiazolidines | pt |
dc.subject | Organocatalyst | pt |
dc.subject | Aldol reaction | pt |
dc.subject | Enantioselective | pt |
dc.subject | Asymmetric synthesis | pt |
dc.subject | Additives | pt |
dc.title | Chiral Thiazolidine based Organocatalysts: Synthesis and Application in Asymmetric Aldol Reactions | pt |
dc.type | article | - |
degois.publication.firstPage | 372 | pt |
degois.publication.lastPage | 380 | pt |
degois.publication.issue | 5 | pt |
degois.publication.title | Letters in Organic Chemistry | pt |
dc.relation.publisherversion | https://www.eurekaselect.com/174165/article | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.2174/2210681209666190807155816 | pt |
degois.publication.volume | 17 | pt |
dc.date.embargo | 2020-12-31 | * |
uc.date.periodoEmbargo | 365 | pt |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-4562-7072 | - |
crisitem.author.orcid | 0000-0002-1391-9855 | - |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Felix2020LettOrgchem.pdf | 305.25 kB | Adobe PDF | View/Open |
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