Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/91152
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dc.contributor.authorFélix, Ana Rita G.-
dc.contributor.authorSimões, Pedro R. D.-
dc.contributor.authorSousa, Francisco J. P. M.-
dc.contributor.authorSerra, Maria Elisa Silva-
dc.contributor.authorMurtinho, Dina-
dc.date.accessioned2020-10-10T11:33:38Z-
dc.date.available2020-10-10T11:33:38Z-
dc.date.issued2020-
dc.identifier.issn15701786pt
dc.identifier.urihttps://hdl.handle.net/10316/91152-
dc.description.abstractSeveral novel chiral organocatalysts derived from thiazolidines containing amide and thioureia functionalities were synthesized in good yields. These organocatalysts were tested in the asymmetric aldol reaction of acetone with p-nitrobenzaldehyde. Reaction parameters such as reaction time, catalyst loading and solvent were optimized. Products with conversions up to 84% and enantiomeric ratios (er) up to 84.5:15.5 (R:S) were obtained. The effect of several chiral and non-chiral additives on the reactivity and selectivity of the reaction was also evaluated. The reaction was extended to other aromatic aldehydes with the best organocatalyst and when p-bromobenzaldehyde was used, an er of 94.5:5.5 (R:S) was obtained.pt
dc.language.isoengpt
dc.publisherBentham Science Publisherspt
dc.relationinfo:eu-repo/grantAgreement/FCT/00313/2019/PTpt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectThiazolidinespt
dc.subjectOrganocatalystpt
dc.subjectAldol reactionpt
dc.subjectEnantioselectivept
dc.subjectAsymmetric synthesispt
dc.subjectAdditivespt
dc.titleChiral Thiazolidine based Organocatalysts: Synthesis and Application in Asymmetric Aldol Reactionspt
dc.typearticle-
degois.publication.firstPage372pt
degois.publication.lastPage380pt
degois.publication.issue5pt
degois.publication.titleLetters in Organic Chemistrypt
dc.relation.publisherversionhttps://www.eurekaselect.com/174165/articlept
dc.peerreviewedyespt
dc.identifier.doi10.2174/2210681209666190807155816pt
degois.publication.volume17pt
dc.date.embargo2020-12-31*
uc.date.periodoEmbargo365pt
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-4562-7072-
crisitem.author.orcid0000-0002-1391-9855-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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