Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/90926
DC FieldValueLanguage
dc.contributor.authorAlves, Cláudia-
dc.contributor.authorGrosso, Carla-
dc.contributor.authorBarrulas, Pedro-
dc.contributor.authorPaixão, José A.-
dc.contributor.authorCardoso, Ana L.-
dc.contributor.authorBurke, Anthony J.-
dc.contributor.authorLemos, Américo-
dc.contributor.authorMelo, Teresa M. V. D. Pinho e-
dc.date.accessioned2020-09-10T15:38:01Z-
dc.date.available2020-09-10T15:38:01Z-
dc.date.issued2019-
dc.identifier.issn0936-5214pt
dc.identifier.issn1437-2096pt
dc.identifier.urihttps://hdl.handle.net/10316/90926-
dc.description.abstractA successful one-pot methodology for the synthesis of chiral 2-tetrazolyl-2H-azirines has been established, resorting to organocatalysis. The protocol involves the in situ tosylation of β-ketoxime-1H-tetrazoles followed by the Neber reaction, in the presence of chiral organocatalysts. Among the organocatalysts studied a novel thiourea catalyst derived from 6β-aminopenicillanic acid afforded excellent enantioselectivities.pt
dc.language.isoengpt
dc.publisherGeorg Thieme Verlagpt
dc.relationUID/QUI/00313/2019pt
dc.relationSFRH/BD/130198/2017pt
dc.relationPD/BD/143159/2019pt
dc.rightsembargoedAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject2H-azirinespt
dc.subjectAsymmetric Neber reactionpt
dc.subjectOrganocatalysispt
dc.subjectTetrazolespt
dc.subjectThioureapt
dc.subject6β-aminopenicillanic acidpt
dc.titleAsymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirinespt
dc.typearticle-
degois.publication.firstPage1pt
degois.publication.lastPage6pt
degois.publication.issue6pt
degois.publication.titleSynlettpt
dc.relation.publisherversionhttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1691533pt
dc.peerreviewedyespt
dc.identifier.doi10.1055/s-0039-1691533pt
degois.publication.volume31pt
dc.date.embargo2020-01-01*
uc.date.periodoEmbargo365pt
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitCFisUC – Center for Physics of the University of Coimbra-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0003-4634-7395-
crisitem.author.orcid0000-0003-0551-7255-
crisitem.author.orcid0000-0001-9588-4555-
crisitem.author.orcid0000-0003-3256-4954-
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais
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