Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/90781
Title: | Tailoring drug and gene codelivery nanosystems for glioblastoma treatment | Authors: | Silva, Jessica Basso, João Mendes, Maria Sousa, João Pais, Alberto Vitorino, Carla |
Keywords: | Co-delivery; Drug delivery; Gene therapy; Glioblastoma; miRNA delivery; Nanoparticle; Nanotherapy | Issue Date: | 2020 | Publisher: | Elsevier | Project: | PEst- OE/QUI/UI0313/2014 POCI-01-0145-FEDER- 016648 POCI-01-0145-FEDER-007440 POCI-01-0145-FEDER-007630 SFRH/BD/133996/2017 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/NEU/04539/2013/PT |
Serial title, monograph or event: | Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents | Abstract: | Glioblastoma is the most common primary and aggressive brain tumour, with an increasing incidence worldwide. The prognosis of this disease is still poor, with a median survival time not exceeding two years. Standard-of-care therapy includes surgical resection, radio- and chemotherapy, but nearly all patients experience progression of the disease. This may be ascribed to the heterogeneity, invasiveness and resistance of tumour cells, along with the struggle that many chemical drugs present in effectively crossing the dual blood brain-blood brain tumour barrier. Considering the hurdles associated to traditional therapeutic approaches, there is a pressing need to improve patient care, as treatments currently available have little effect on the overall survival. Therefore, the use of adjuvant chemotherapeutics in combination with temozolomide, a first-line drug, and novel molecularly-targeted approaches against both tumor and stem cells and respective microenvironment are under investigation. This chapter addresses the development of innovative multi-target nanomedicines, comprising complementary chemo- (e.g. temozolomide) and gene therapeutic (antimiR and miRNA mimic) agents, combined with targeting ligands within a single nanostructure directed at the treatment of glioblastoma multiforme. The approach aims at providing significantly improved therapeutics, as treatments currently available have little effect on overall survival. | URI: | https://hdl.handle.net/10316/90781 | ISBN: | 9780128196663 | DOI: | 10.1016/B978-0-12-819666-3.00005-5 | Rights: | embargoedAccess |
Appears in Collections: | I&D CQC - Livros e capítulos de livros |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Chapter 5.pdf | 695.84 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
2
checked on Sep 2, 2024
Page view(s)
243
checked on Oct 9, 2024
Download(s)
210
checked on Oct 9, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.