Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/90486
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Boia, Raquel | - |
dc.contributor.author | Ruzafa, Noelia | - |
dc.contributor.author | Aires, Inês Dinis | - |
dc.contributor.author | Pereiro, Xandra | - |
dc.contributor.author | Ambrósio, António Francisco | - |
dc.contributor.author | Vecino, Elena | - |
dc.contributor.author | Santiago, Ana Raquel | - |
dc.date.accessioned | 2020-08-03T16:41:21Z | - |
dc.date.available | 2020-08-03T16:41:21Z | - |
dc.date.issued | 2020-03-25 | - |
dc.identifier.issn | 1422-0067 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/90486 | - |
dc.description.abstract | The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving the patients with optic neuropathies with permanent visual loss. An effective RGCs-directed therapy could provide a beneficial effect to prevent the progression of the disease. Axonal injury leads to the functional loss of RGCs and subsequently induces neuronal death, and axonal regeneration would be essential to restore the neuronal connectivity, and to reestablish the function of the visual system. The manipulation of several intrinsic and extrinsic factors has been proposed in order to stimulate axonal regeneration and functional repairing of axonal connections in the visual pathway. However, there is a missing point in the process since, until now, there is no therapeutic strategy directed to promote axonal regeneration of RGCs as a therapeutic approach for optic neuropathies. | pt |
dc.description.sponsorship | This work was supported by Foundation for Science and Technology (FCT), Portugal (Fellowships PD/BD/114115/2015 and PD/BD/127821/2016, Grant PTDC/NEU-OSD/3123/2014 and Strategic Projects UID/NEU/04539/2013, UID/NEU/04539/2019, UIDP/04539/2020 and UIDB/04539/2020), FEDER-COMPETE POCI-01-0145-FEDER-016849, FCOMP-01-0124-FEDER-028417, POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BrainHealth 2020). Grupos UPV/EHU GIU18/50, PUE 2018-04 and ELKARTEK KK-2019/00086 to E.V. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | Portuguese Foundation for Science and Technology | pt |
dc.relation | European Union (EU) | pt |
dc.relation | Centro 2020 Regional Operational Programme | pt |
dc.relation | Grupo UPV/EHU | pt |
dc.relation | Grupo PUE | pt |
dc.relation | Grupo ELKARTEK | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt |
dc.subject | retinal ganglion cells | pt |
dc.subject | neurodegeneration | pt |
dc.subject | axonal regeneration | pt |
dc.subject | neuroprotection | pt |
dc.subject | optic neuropathies | pt |
dc.title | Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead | pt |
dc.type | article | - |
degois.publication.firstPage | 2262 | pt |
degois.publication.issue | 7 | pt |
degois.publication.location | ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND | pt |
degois.publication.title | International Journal of Molecular Sciences | pt |
dc.relation.publisherversion | ijms-21-02262-v2.pdf | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/ijms21072262 | pt |
degois.publication.volume | 21 | pt |
dc.date.embargo | 2020-03-25 | * |
uc.date.periodoEmbargo | 0 | pt |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-0477-1641 | - |
crisitem.author.orcid | 0000-0002-7541-7041 | - |
Appears in Collections: | I&D IBILI - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Boia-2020-Neuroprotective-strategies-for-reti.pdf | 6.15 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
37
checked on Nov 17, 2022
WEB OF SCIENCETM
Citations
10
37
checked on May 2, 2023
Page view(s)
275
checked on Apr 24, 2024
Download(s)
215
checked on Apr 24, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License