Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/87807
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gomes, Pedro | - |
dc.contributor.author | Leal, Helena | - |
dc.contributor.author | Mendes, Alexandrina F. | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Cavadas, Cláudia | - |
dc.date.accessioned | 2019-11-15T12:41:58Z | - |
dc.date.available | 2019-11-15T12:41:58Z | - |
dc.date.issued | 2019-11-05 | - |
dc.identifier.issn | 01656147 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/87807 | - |
dc.description.abstract | Sirtuins (SIRT1-7), a class of NAD+-dependent deacylases, are central regulators of metabolic homeostasis and stress responses. While numerous salutary effects associated with sirtuin activation, especially SIRT1, are well documented, other reports show health benefits resulting from sirtuin inhibition. Furthermore, conflicting findings have been obtained regarding the pathophysiological role of specific sirtuin isoforms, suggesting that sirtuins act as 'double-edged swords'. Here, we provide an integrated overview of the different findings on the role of mammalian sirtuins in neurodegenerative and cardiometabolic disorders and attempt to dissect the reasons behind these different effects. Finally, we discuss how addressing these obstacles may provide a better understanding of the complex sirtuin biology and improve the likelihood of identifying effective and selective drug targets for a variety of human disorders. | pt |
dc.language.iso | por | pt |
dc.rights | embargoedAccess | pt |
dc.subject | age-related diseases; cardiometabolic diseases; genetic manipulations; neurodegeneration; pharmacological modulators; sirtuins | pt |
dc.title | Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases | pt |
dc.type | article | - |
degois.publication.title | Trends Pharmacolological Sciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1016/j.tips.2019.09.003 | pt |
dc.date.embargo | 2025-11-03 | * |
uc.date.periodoEmbargo | 2190 | pt |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | embargo_20251103 | - |
item.languageiso639-1 | pt | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.orcid | 0000-0003-1766-9133 | - |
crisitem.author.orcid | 0000-0001-5511-7132 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0001-8020-9266 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | Login |
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1-s2.0-S0165614719302147-main.pdf | 1.56 MB | Adobe PDF | Embargo Access Request a copy |
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