Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8449
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dc.contributor.authorGarrido, J. M. P. J.-
dc.contributor.authorDelerue-Matos, C.-
dc.contributor.authorBorges, F.-
dc.contributor.authorMacedo, T. R. A.-
dc.contributor.authorBrett, A. M. Oliveira-
dc.date.accessioned2009-02-09T14:53:35Z-
dc.date.available2009-02-09T14:53:35Z-
dc.date.issued2004en_US
dc.identifier.citationElectroanalysis. 16:17 (2004) 1419-1426en_US
dc.identifier.urihttp://hdl.handle.net/10316/8449-
dc.description.abstractA detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a C-O coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleVoltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolitesen_US
dc.typearticleen_US
dc.identifier.doi10.1002/elan.200302966en_US
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0001-8981-231X-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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