Title: No evidence of association or linkage disequilibrium between polymorphisms in the 5prime upstream and coding regions of the dopamine D4 receptor gene and schizophrenia in a Portuguese population
Authors: Ambrósio, Alda M. 
Kennedy, James L. 
Macciardi, Fabio 
Barr, Cathy 
Soares, Maria J. 
Oliveira, Catarina R. 
Pato, Carlos N. 
Issue Date: 2004
Citation: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 125B:1 (2004) 20-24
Abstract: Alterations in dopaminergic system have been implicated in the pathophysiology of this disease for many years, and this study was performed to assess the possible involvement of the dopamine D4 receptor (DRD4) gene polymorphisms either in the 5prime upstream or in the coding regions, in the etiology of schizophrenia. The approach included an association study with 90 Portuguese trios by doing the analysis of the individual alleles and the haplotypes. For the polymorphisms in the 5prime upstream region (-C616G and -C521T) and in the coding region (48 bp repeat) of the DRD4 gene, negative results were obtained with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT), as well as transmit. These data suggest that polymorphisms (-C616G, -C521T, and 48 bp repeat) at the DRD4 gene do not have a minor effect in the susceptibility to schizophrenia in our sample. © 2003 Wiley-Liss, Inc.
URI: http://hdl.handle.net/10316/8428
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
obra.pdf66.14 kBAdobe PDFView/Open
Show full item record
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.