Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8403
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dc.contributor.authorPinto, Maria de Lurdes-
dc.contributor.authorRodrigues, Paula-
dc.contributor.authorCoelho, Ana Cláudia-
dc.contributor.authorPires, Maria dos Anjos-
dc.contributor.authorSantos, Dario Loureiro dos-
dc.contributor.authorGonçalves, Carlos-
dc.contributor.authorBairos, Vasco António-
dc.date.accessioned2009-02-09T14:53:14Z-
dc.date.available2009-02-09T14:53:14Z-
dc.date.issued2007en_US
dc.identifier.citationInternational Journal of Experimental Pathology. 88:6 (2007) 393-401en_US
dc.identifier.urihttp://hdl.handle.net/10316/8403-
dc.description.abstractVitamin A and the retinoids play a unique role in mammalian embryonic and foetal development and are essential for both cellular differentiation and the establishment of normal morphogenesis. Vascular endothelial growth factor (VEGF) is a known potent mitogenic factor that plays a key role in lung development and function maintenance. In order to contribute to a better knowledge of the modulating effects of vitamin A in lung development, we investigated the effects of the antenatal administration of vitamin A on VEGF expression in lungs and plasma from foetuses and neonates. Pregnant mice were subjected to subcutaneous administration of vitamin A on the 12th gestational day. The lungs and plasma from foetuses and neonates were collected daily from the 15th gestational day till the day of birth. Our results show that vitamin A modulates VEGF concentrations both in lungs and plasma. Statistically significant differences were observed at gestational days 15 (P = 0.004 for lungs; P < 0.0001 for plasma), 16 (P < 0.0001 for lungs and plasma) and 18 (P < 0.0001 for lungs; P < 0.05 for plasma). Vitamin A tends to increase the expression of this factor in the lung, particularly during the critical period of perinatal adaptation to postnatal life. These effects seem to be spatial and temporally regulated, and point out to the important role of vitamin A during lung development.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titlePrenatal administration of vitamin A alters pulmonary and plasma levels of vascular endothelial growth factor in the developing mouseen_US
dc.typearticleen_US
dc.identifier.doi10.1111/j.1365-2613.2007.00565.xen_US
uc.controloAutoridadeSim-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sports Sciences and Physical Education-
crisitem.author.researchunitCIDAF - Research Unit for Sport and Physical Activity-
crisitem.author.orcid0000-0002-6687-9041-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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