Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/8305
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dc.contributor.authorBrett, Ana Maria Oliveira-
dc.contributor.authorSerrano, Sílvia H. P.-
dc.contributor.authorMacedo, Tice A.-
dc.contributor.authorRaimundo, Dulce-
dc.contributor.authorMarques, M. Helena-
dc.contributor.authorLa-Scalea, Mauro A.-
dc.date.accessioned2009-02-09T14:31:40Z-
dc.date.available2009-02-09T14:31:40Z-
dc.date.issued1996en_US
dc.identifier.citationElectroanalysis. 8:11 (1996) 992-995en_US
dc.identifier.urihttp://hdl.handle.net/10316/8305-
dc.description.abstractAn electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics corresponding to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 × 10 -6M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.en_US
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleElectrochemical determination of carboplatin in serum using a DNA-modified glassy carbon electrodeen_US
dc.typearticleen_US
dc.identifier.doi10.1002/elan.1140081104en_US
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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