Title: 2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: photosensitization efficiency, subcellular localization and in vivo studies
Authors: Laranjo, Mafalda 
Serra, Arménio C 
Abrantes, Margarida 
Piñeiro, Marta 
Gonçalves, Ana C 
Casalta-Lopes, João 
Carvalho, Lina 
Sarmento-Ribeiro, Ana B 
Rocha-Gonsalves, António 
Botelho, Filomena 
Issue Date: Feb-2013
Abstract: Photodynamic therapy (PDT) is a therapeutic modality capable of inducing cell death by oxidative stress through activation of a sensitizer by light. Aryl-porphyrin with hydroxyl groups are good photosensitizers and presence of bromine atoms can enhance the photodynamic activity through heavy atom effect. These facts and our previous work made pertinent to compare the photodynamic capacity of tetraaryl brominated porphyrin (TBr4) with the corresponding diaryl (BBr2) derivative.
URI: http://hdl.handle.net/10316/80879
ISSN: 1873-1597
DOI: 10.1016/j.pdpdt.2012.05.003
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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