Title: Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed Stealth Liposomes with Retention of Binding Activity and Cytotoxicity
Authors: Moreira, João N. 
Ishida, Tatsuhiro 
Gaspar, Rogério 
Allen, Theresa M. 
Issue Date: 2002
Citation: Pharmaceutical Research. 19:3 (2002) 265-269
Abstract: Purpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for inserting peptide ligands into preformed Stealth liposomes. Antagonist G-targeted liposomes (PLG) were prepared and loaded with doxorubicin and their cellular association and cytotoxicity were evaluated using the human small cell lung cancer H69 cell line.
URI: http://hdl.handle.net/10316/7964
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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