Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/7953
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Figueiras, Ana | - |
dc.contributor.author | Ribeiro, Laura | - |
dc.contributor.author | Torres-Labandeira, J. | - |
dc.contributor.author | Veiga, Francisco J. | - |
dc.date.accessioned | 2009-02-17T10:49:07Z | - |
dc.date.available | 2009-02-17T10:49:07Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:1 (2007) 531-535 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/7953 | - |
dc.description.abstract | Abstract Interactions between a benzimidazolic derivative, omeprazole (OME), beta-cyclodextrin (ßCD) and a chemically modified ßCD, methyl-beta-cyclodextrin (MßCD) were investigated in aqueous solution by UV-VIS spectroscopy and in solid state by differential scanning calorimetry (DSC). Phase solubility studies were used to evaluate the complexation in aqueous solution. The two solubility diagrams obtained were AL type, indicating the formation of a drug-cyclodextrin complex with 1:1 stoichiometry. The complex of OME with MßCD showed a higher stability constant (K S) than those with ßCD. Some evidences of inclusion complexation in solid state were obtained from DSC. Only in thermal curves of OME-ßCD lyophilized product and in OME-MßCD spray-dried and lyophilized systems the melting point of the drug disappeared completely suggesting the possible formation of an inclusion complex. | en_US |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.title | Evaluation of host-guest complex formation between a benzimidazolic derivative and cyclodextrins by UV-VIS spectrophotometry and differential scanning calorimetry | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1007/s10847-006-9245-4 | en_US |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-8170-1113 | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
SCOPUSTM
Citations
11
checked on Aug 12, 2024
WEB OF SCIENCETM
Citations
5
12
checked on Aug 2, 2024
Page view(s) 50
512
checked on Aug 13, 2024
Download(s) 50
446
checked on Aug 13, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.