Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5830
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Silva, Cláudia L. | - |
dc.contributor.author | Pereira, Jorge C. | - |
dc.contributor.author | Ramalho, Amílcar | - |
dc.contributor.author | Pais, Alberto A. C. C. | - |
dc.contributor.author | Sousa, João J. S. | - |
dc.date.accessioned | 2008-09-26T17:42:31Z | - |
dc.date.available | 2008-09-26T17:42:31Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Journal of Membrane Science. 320:1-2 (2008) 268-279 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5830 | - |
dc.description.abstract | Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pKa of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6TGK-4S8CR51-5/1/cdb82032d8e533445099d1ce53f2922a | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Chitosan | en_US |
dc.subject | Polyelectrolyte complexes | en_US |
dc.subject | Glycerol | en_US |
dc.subject | Skin drug delivery | en_US |
dc.title | Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.memsci.2008.04.011 | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0002-8633-3716 | - |
crisitem.author.orcid | 0000-0001-7004-2212 | - |
crisitem.author.orcid | 0000-0002-6725-6460 | - |
crisitem.author.orcid | 0000-0001-9718-8035 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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filea37754682d6f4f84939ae4a0ee8f44cc.pdf | 1.67 MB | Adobe PDF | View/Open |
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