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https://hdl.handle.net/10316/5794
Title: | Targeting Stealth liposomes in a murine model of human small cell lung cancer | Authors: | Moreira, João N. Gaspar, Rogério Allen, Theresa M. |
Keywords: | Pegylated liposome; Doxorubicin; Targeting; Antagonist G; Small cell lung cancer | Issue Date: | 2001 | Citation: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1515:2 (2001) 167-176 | Abstract: | Tumor accumulation and therapeutic activity of Stealth liposomes loaded with doxorubicin (DXR) were examined in Balb/c nude mice xenografts inoculated subcutaneously with the human small cell lung cancer (SCLC) cell line, H69. Mice were treated with non-targeted liposomes (SL) or liposomes targeted with antagonist G coupled to the liposome surface (SLG). SLG showed 30-44-fold higher binding to H69 cells harvested from H69 xenografts than SL. At 48 and 72 h post injection, tumor accumulation of [125I]tyraminylinulin-containing liposomes was shown to be dependent on liposome size but independent of the presence of the targeting ligand. Maximum tumor uptake of either SLG or SL ranged from 2 to 4% of injected dose/g of tissue. In therapeutic studies, mice received three weekly injections of 3 or 6 mg free DXR/kg or 3 or 10 mg liposomal DXR/kg at initial tumor volumes of either 7 or 33 mm3. The therapeutic efficacy of DXR-containing SL or SLG was significantly improved over free DXR, but SLG did not improve anti-tumor efficacy relative to SL. Stealth liposomes containing DXR have potential as a therapy against human SCLC tumors. | URI: | https://hdl.handle.net/10316/5794 | DOI: | 10.1016/S0005-2736(01)00411-4 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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