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https://hdl.handle.net/10316/5771
Title: | The biocatalyzed stereoselective preparation of polycyclic cyanohydrins | Authors: | Silva, M. Manuel Cruz Melo, M. Luísa Sá e Parolin, Marco Tessaro, Davide Riva, Sergio Danieli, Bruno |
Issue Date: | 2004 | Citation: | Tetrahedron: Asymmetry. 15:1 (2004) 21-27 | Abstract: | The enzyme-mediated preparation of enantiomerically or diastereomerically enriched polycyclic cyanohydrins has been investigated. Oxynitrilase-catalyzed cyanurations gave excellent results with the bicyclic aldehydes tested. On the other hand, enantio- or diastereoselective acylation, catalyzed by lipase PS or subtilisin, proved to be a more versatile methodology, giving good results even with sterically hindered polycyclic cyanohydrins. Specifically, the steroidal cyanohydrin derivative 4b was isolated with a 89% de. | URI: | https://hdl.handle.net/10316/5771 | DOI: | 10.1016/j.tetasy.2003.11.003 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
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