Title: The biocatalyzed stereoselective preparation of polycyclic cyanohydrins
Authors: Silva, M. Manuel Cruz 
Melo, M. Luísa Sá e 
Parolin, Marco 
Tessaro, Davide 
Riva, Sergio 
Danieli, Bruno 
Issue Date: 2004
Citation: Tetrahedron: Asymmetry. 15:1 (2004) 21-27
Abstract: The enzyme-mediated preparation of enantiomerically or diastereomerically enriched polycyclic cyanohydrins has been investigated. Oxynitrilase-catalyzed cyanurations gave excellent results with the bicyclic aldehydes tested. On the other hand, enantio- or diastereoselective acylation, catalyzed by lipase PS or subtilisin, proved to be a more versatile methodology, giving good results even with sterically hindered polycyclic cyanohydrins. Specifically, the steroidal cyanohydrin derivative 4b was isolated with a 89% de.
URI: http://hdl.handle.net/10316/5771
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
file42ab76357605461bad2204cc7e2f9431.pdf299.85 kBAdobe PDFView/Open
Show full item record
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.