Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/5767
Title: Highly selective lipase-mediated discrimination of diastereomeric 5,6-epoxysteroids
Authors: Silva, M. Manuel Cruz 
Riva, Sergio 
Melo, M. Luísa Sá e 
Issue Date: 2004
Citation: Tetrahedron: Asymmetry. 15:7 (2004) 1173-1179
Abstract: Stereoisomerically pure 3[beta]-hydroxy-5,6-epoxysteroids were obtained by combining selective chemical methods for [alpha]- and [beta]-epoxidation of [Delta]5-unsaturated steroids with enzymatic stereoselective esterification of the 3[beta]-hydroxyl group. 5[beta],6[beta]-Epoxy-3[beta]-hydroxysteroids were efficiently acylated by Novozym 435 and lipase AK, whereas 5[alpha],6[alpha]-epoxy-3[beta]-hydroxysteroids were good substrates for Candida rugosa lipase. Mild enzymatic deacylation of the 3[beta]-acetoxy group in the presence of the epoxy functionality was also accomplished by C. rugosa lipase-mediated hydrolysis.
URI: http://hdl.handle.net/10316/5767
DOI: 10.1016/j.tetasy.2004.02.010
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
file76b01d72533f40a89f04b2e4320c4e33.pdf341.69 kBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations 20

15
checked on Jan 2, 2021

Page view(s) 1

1,908
checked on Jan 21, 2021

Download(s)

159
checked on Jan 21, 2021

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.