Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5269
Title: | Electrochemical oxidation of mitoxantrone at a glassy carbon electrode | Authors: | Brett, A. M. Oliveira Macedo, T. R. A. Raimundo, D. Marques, M. H. Serrano, S. H. P. |
Keywords: | Bioelectrochemistry; Mitoxantrone oxidation; Voltammetry | Issue Date: | 1999 | Citation: | Analytica Chimica Acta. 385:1-3 (1999) 401-408 | Abstract: | Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10-7 M. | URI: | https://hdl.handle.net/10316/5269 | DOI: | 10.1007/BF01206688 | Rights: | openAccess |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
filed0d8454e13cb4ecc9acb56bbce2c382f.pdf | 256.81 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
9
checked on Sep 16, 2024
Page view(s)
309
checked on Sep 10, 2024
Download(s)
290
checked on Sep 10, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.