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Title: Singlet oxygen quantum yields from halogenated chlorins: potential new photodynamic therapy agents
Authors: Pineiro, Marta 
Pereira, Mariette M. 
Rocha Gonsalves, A. M. d'A. 
Arnaut, Luis G. 
Formosinho, Sebastião J. 
Keywords: Photoacoustic calorimetry; Chlorin; Singlet oxygen; Sensitisers; Photodynamic therapy
Issue Date: 2001
Citation: Journal of Photochemistry and Photobiology A: Chemistry. 138:2 (2001) 147-157
Abstract: Flash photolysis and photoacoustic calorimetry were used to measure the energy-transfer rates and singlet oxygen quantum yields originated by the triplet states of halogenated tetrakisphenylporphyrins and related chlorins in aerated toluene. The chlorins ([lambda]max[approximate]660 nm, [var epsilon][approximate]3×104 M-1 cm-1) have long-lived triplet states (>12 [mu]s) in the absence of molecular oxygen, and in its presence the singlet oxygen production quantum yields of the 2-chloro and 2,6-dichlorophenyl derivatives are 0.89±0.05 and 0.98±0.02, respectively. The high absorptivity in the red, the photostability and the efficiency of these chlorins in producing singlet oxygen suggests a ground for the development of better sensitisers for photodynamic therapy.
DOI: 10.1016/S1010-6030(00)00382-8
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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