Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/5192
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira-Brett, A. M. | - |
dc.contributor.author | Vivan, M. | - |
dc.contributor.author | Fernandes, I. R. | - |
dc.contributor.author | Piedade, J. A. P. | - |
dc.date.accessioned | 2008-09-01T15:05:32Z | - |
dc.date.available | 2008-09-01T15:05:32Z | - |
dc.date.issued | 2002 | en_US |
dc.identifier.citation | Talanta. 56:5 (2002) 959-970 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/5192 | - |
dc.description.abstract | Adriamycin intercalation and in situ interaction with double helix DNA was investigated using a voltammetric DNA-biosensor. Oxidation and reduction of adriamycin molecules intercalated in double helix DNA were investigated in order to understand the in vivo mechanism of action with this anti-neoplasic drug. The results showed that the interaction of adriamycin with DNA is potential-dependent causing contact between DNA guanine and adenine bases and the electrode surface such that their oxidation is easily detected. A mechanism for adriamycin reduction and oxidation in situ when intercalated in double helix DNA immobilised onto the glassy carbon electrode surface is presented and the formation of the mutagenic 8-oxoguanine explained. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6THP-44PVS7R-M/1/1474d369a4b1d556b84d548d2df25439 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Adriamycin | en_US |
dc.subject | DNA-biosensor | en_US |
dc.subject | Oxidative damage | en_US |
dc.subject | 8-Oxoguanine | en_US |
dc.subject | Voltammetry | en_US |
dc.title | Electrochemical detection of in situ adriamycin oxidative damage to DNA | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0039-9140(01)00656-7 | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CEMMPRE - Centre for Mechanical Engineering, Materials and Processes | - |
crisitem.author.orcid | 0000-0002-6244-0891 | - |
Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais |
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file1cc3b0c62ec84011af7d7ac3c95dd182.pdf | 217.2 kB | Adobe PDF | View/Open |
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