Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/5192
DC FieldValueLanguage
dc.contributor.authorOliveira-Brett, A. M.-
dc.contributor.authorVivan, M.-
dc.contributor.authorFernandes, I. R.-
dc.contributor.authorPiedade, J. A. P.-
dc.date.accessioned2008-09-01T15:05:32Z-
dc.date.available2008-09-01T15:05:32Z-
dc.date.issued2002en_US
dc.identifier.citationTalanta. 56:5 (2002) 959-970en_US
dc.identifier.urihttps://hdl.handle.net/10316/5192-
dc.description.abstractAdriamycin intercalation and in situ interaction with double helix DNA was investigated using a voltammetric DNA-biosensor. Oxidation and reduction of adriamycin molecules intercalated in double helix DNA were investigated in order to understand the in vivo mechanism of action with this anti-neoplasic drug. The results showed that the interaction of adriamycin with DNA is potential-dependent causing contact between DNA guanine and adenine bases and the electrode surface such that their oxidation is easily detected. A mechanism for adriamycin reduction and oxidation in situ when intercalated in double helix DNA immobilised onto the glassy carbon electrode surface is presented and the formation of the mutagenic 8-oxoguanine explained.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6THP-44PVS7R-M/1/1474d369a4b1d556b84d548d2df25439en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectAdriamycinen_US
dc.subjectDNA-biosensoren_US
dc.subjectOxidative damageen_US
dc.subject8-Oxoguanineen_US
dc.subjectVoltammetryen_US
dc.titleElectrochemical detection of in situ adriamycin oxidative damage to DNAen_US
dc.typearticleen_US
dc.identifier.doi10.1016/S0039-9140(01)00656-7-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.researchunitCEMMPRE - Centre for Mechanical Engineering, Materials and Processes-
crisitem.author.orcid0000-0002-6244-0891-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
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