Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4860
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pauwels, E. K. J. | - |
dc.contributor.author | Ribeiro, M. J. | - |
dc.contributor.author | Stoot, J. H. M. B. | - |
dc.contributor.author | McCready, V. R. | - |
dc.contributor.author | Bourguignon, M. | - |
dc.contributor.author | Mazière, B. | - |
dc.date.accessioned | 2008-09-01T14:15:43Z | - |
dc.date.available | 2008-09-01T14:15:43Z | - |
dc.date.issued | 1998 | en_US |
dc.identifier.citation | Nuclear Medicine and Biology. 25:4 (1998) 317-322 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4860 | - |
dc.description.abstract | The tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T9Y-3T6YJSP-R/1/fbaf3f2de58361e6bcbacfe1ec6d3199 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Scintigraphy | en_US |
dc.subject | Fluorodeoxyglucose | en_US |
dc.subject | Tumor biology | en_US |
dc.title | FDG Accumulation and Tumor Biology | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/S0969-8051(97)00226-6 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-6422-3279 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
filee75bca7ea38144cdaf3134d051016923.pdf | 301.56 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
317
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
280
checked on Oct 2, 2024
Page view(s) 50
548
checked on Oct 15, 2024
Download(s) 20
1,480
checked on Oct 15, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.