Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/4769
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dc.contributor.authorLee, Hyoung-gon-
dc.contributor.authorPerry, George-
dc.contributor.authorMoreira, Paula I.-
dc.contributor.authorGarrett, Matthew R.-
dc.contributor.authorLiu, Quan-
dc.contributor.authorZhu, Xiongwei-
dc.contributor.authorTakeda, Atsushi-
dc.contributor.authorNunomura, Akihiko-
dc.contributor.authorSmith, Mark A.-
dc.date.accessioned2008-09-01T14:14:09Z-
dc.date.available2008-09-01T14:14:09Z-
dc.date.issued2005en_US
dc.identifier.citationTrends in Molecular Medicine. 11:4 (2005) 164-169en_US
dc.identifier.urihttp://hdl.handle.net/10316/4769-
dc.description.abstractDuring the past decade, hypotheses concerning the pathogenesis of most neurodegenerative diseases have been dominated by the notion that the aggregation of specific proteins and subsequent formation of cytoplasmic and extracellular lesions represent a harbinger of neuronal dysfunction and death. As such, in Alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is considered a central mediator of disease pathogenesis. We challenge this classic notion by proposing that tau phosphorylation represents a compensatory response mounted by neurons against oxidative stress and serves a protective function. This novel concept, which can also be applied to protein aggregates in other neurodegenerative diseases, opens a new window of knowledge with broad implications for both the understanding of mechanisms underlying disease pathophysiology and the design of new therapeutic strategies.en_US
dc.description.urihttp://www.sciencedirect.com/science/article/B6W7J-4FNNC51-2/1/3fd57243f3b01d6654fbf488fd3d00a0en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleTau phosphorylation in Alzheimer's disease: pathogen or protector?en_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.molmed.2005.02.008-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-5177-6747-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
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