Title: Simulated annealing applied to IMRT beam angle optimization: A computational study
Authors: Dias, Joana 
Rocha, Humberto 
Ferreira, Brígida 
Lopes, Maria do Carmo 
Keywords: Algorithms;Head and Neck Neoplasms;Humans;Radiotherapy Planning, Computer-Assisted;Radiotherapy, Intensity-Modulated;Retrospective Studies
Issue Date: 2015
Abstract: Electing irradiation directions to use in IMRT treatments is one of the first decisions to make in treatment planning. Beam angle optimization (BAO) is a difficult problem to tackle from the mathematical optimization point of view. It is highly non-convex, and optimization approaches based on gradient descent methods will probably get trapped in one of the many local minima. Simulated Annealing (SA) is a local search probabilistic procedure that is known to be able to deal with multimodal problems. SA for BAO was retrospectively applied to ten clinical examples of treated cases of head-and neck tumors signalized as complex cases where proper target coverage and organ sparing proved difficult to achieve. The number of directions to use was considered fixed and equal to 5 or 7. It is shown that SA can lead to solutions that significantly improve organ sparing, even considering a reduced number of angles, without jeopardizing tumor coverage.
URI: http://hdl.handle.net/10316/44632
Other Identifiers: 10.1016/j.ejmp.2015.03.005
Rights: openAccess
Appears in Collections:FEUC- Artigos em Revistas Internacionais

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