Title: Performance of gentamicin population kinetic parameters in Portuguese neonates
Authors: Rocha, Marília J. 
Almeida, Anabela M. 
Falcão, Amílcar 
Caramona, Margarida M. 
Keywords: Gentamicin;Infant;Newborn;Pharmacokinetics;Prediction error
Issue Date: 2007
Publisher: Springer
Citation: Rocha, Marília J.; Almeida, Anabela M. ; Falcão, Amílcar C.; Caramona, Margarida M. - Performance of gentamicin population kinetic parameters in Portuguese neonates. Pharm World Sci 29 (2007)104–108
Abstract: Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA), receiving gentamicin, and for whom peak and trough concentrations were obtained. Accuracy and precision were assessed by mean prediction error (ME), mean squared prediction error (MSE) and root mean squared prediction error (RMSE). Weighted prediction-error analysis was carried out in order to evaluate peak and trough concentrations together (MEw, MSEw and RMSEw). Results: The analysis showed CL=0.036 l/h/kg (<34 weeks GA) or CL=0.051 l/h/kg (‡34 weeks GA), and Vd=0.5 l/kg (£37 weeks GA) or Vd=0.4 l/kg (>37 weeks of GA) as the most accurate and precise set of pharmacokinetic parameters (Set 4), presenting the highest percentage of clinically acceptable estimates (ErrorPeak<1 lg/ml, and ErrorTrough <0.375 lg/ml). Conclusion: The adoption of the previously mentioned set of parameters as population estimates seems to be the best option, bearing in mind the obtained results. However, we strongly believe that pharmacokinetic parameter determination of gentamicin should be carried out whenever possible in order to improve the rationale and cost-effectiveness of therapy.
URI: http://hdl.handle.net/10316/2802
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
PWS.pdf183.91 kBAdobe PDFView/Open
Show full item record
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.