Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27929
Title: | Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles | Authors: | Santos, Kathleen Laranjo, Mafalda Abrantes, Ana Margarida Brito, Ana F. Gonçalves, Cristina Ribeiro, Ana Bela Sarmento Botelho, M. Filomena Soares, Maria I. L. Oliveira, Andreia S. R. Melo, Teresa M. V. D. Pinho e |
Keywords: | 6,7-Bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazole; Antitumor activity; Breast cancer; Triple-negative breast cancer | Issue Date: | 22-May-2014 | Publisher: | Elsevier | Citation: | SANTOS, Kathleen [et. al] - Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. "European Journal of Medicinal Chemistry". ISSN 0223-5234. Vol. 79 (2014) p. 273–281 | Serial title, monograph or event: | European Journal of Medicinal Chemistry | Volume: | 79 | Abstract: | Further studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HCC1806 cell lines). Particularly interesting were the results obtained for 4-hydroxyphenyl substituted derivative, which proved to be the most promising compound regarding HCC1806 cell line, a triple-negative breast cancer. The effects of the two most active compounds on cell survival, viability, cell cycle, DNA damage and expression of proteins related to cell death pathways were studied. The reported results consolidate the potential of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles for the therapy of breast cancer, particularly the triple-negative. | URI: | https://hdl.handle.net/10316/27929 | ISSN: | 0223-5234 | DOI: | 10.1016/j.ejmech.2014.04.008 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FCTUC Química - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Targeting triple-negative breast cancer cells.pdf | 1.79 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
30
checked on Oct 14, 2024
WEB OF SCIENCETM
Citations
5
29
checked on Oct 2, 2024
Page view(s) 50
471
checked on Oct 8, 2024
Download(s) 50
578
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.