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Title: Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles
Authors: Santos, Kathleen 
Laranjo, Mafalda 
Abrantes, Ana Margarida 
Brito, Ana F. 
Gonçalves, Cristina 
Ribeiro, Ana Bela Sarmento 
Botelho, M. Filomena 
Soares, Maria I. L. 
Oliveira, Andreia S. R. 
Melo, Teresa M. V. D. Pinho e 
Keywords: 6,7-Bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazole; Antitumor activity; Breast cancer; Triple-negative breast cancer
Issue Date: 22-May-2014
Publisher: Elsevier
Citation: SANTOS, Kathleen [et. al] - Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles. "European Journal of Medicinal Chemistry". ISSN 0223-5234. Vol. 79 (2014) p. 273–281
Serial title, monograph or event: European Journal of Medicinal Chemistry
Volume: 79
Abstract: Further studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HCC1806 cell lines). Particularly interesting were the results obtained for 4-hydroxyphenyl substituted derivative, which proved to be the most promising compound regarding HCC1806 cell line, a triple-negative breast cancer. The effects of the two most active compounds on cell survival, viability, cell cycle, DNA damage and expression of proteins related to cell death pathways were studied. The reported results consolidate the potential of 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles for the therapy of breast cancer, particularly the triple-negative.
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2014.04.008
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais
FCTUC Química - Artigos em Revistas Internacionais

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