Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27852
DC FieldValueLanguage
dc.contributor.authorRibeiro, Márcio-
dc.contributor.authorRosenstock, Tatiana R.-
dc.contributor.authorOliveira, Ana M.-
dc.contributor.authorOliveira, Catarina R.-
dc.contributor.authorRego, A. Cristina-
dc.date.accessioned2014-12-10T11:47:37Z-
dc.date.available2014-12-10T11:47:37Z-
dc.date.issued2014-09-
dc.identifier.citationRIBEIRO, Márcio [et. al] - Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells. "Free Radical Biology and Medicine". ISSN 0891-5849. Vol. 74 (2014) p. 129–144por
dc.identifier.issn0891-5849-
dc.identifier.urihttp://hdl.handle.net/10316/27852-
dc.description.abstractAkt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related protein 1 or dynamin 1-like (DNM1L); GCL, glutamate-cysteine ligase; GCLc, glutamate-cysteine catalytic subunit; GPx, glutathione peroxidase; GSH, glutathione, reduced form; GSSG, glutathione oxidized form; IGF-1, Insulin-like growth factor 1; IGF1R, insulin-like growth factor 1 receptor; IR, insulin receptor; IRS, insulin receptor substrate; H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; HKII, hexokinase type II; HD, Huntington’s disease; HO-1, heme oxygenase; Hsp60, heat shock 60 kDa protein 1 (chaperonin); mHtt, mutant huntingtin; mtDNA, mitochondrial DNA; MT-COII, mitochondrial-encoded cytochrome c oxidase II; mTOR, mammalian target of rapamycin; NDUFS3, NADH dehydrogenase (ubiquinone) Fe–S protein 3, 30 kDa (NADH-coenzyme Q reductase); NQO1, NAD(P)H dehydrogenase [quinone] 1; Nrf2, nuclear factor (erythroid-derived 2)-like 2; PI-3K, phosphatidylinositol 3-kinase; PGC-1α, peroxisome proliferator-activated receptor-γ coactivator 1α; ROS, reactive oxygen species; SDHA, succinate dehydrogenase complex, subunit A, flavoprotein (Fp); SOD, superoxide dismutase; Tfam, transcription factor A, mitochondrial; TMRM, tetramethylrhodamine methyl ester; Tom20, translocase of outer mitochondrial membrane 20 homolog (yeast); Tom40, translocase of outer mitochondrial membrane 40 homolog (yeast).por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectHuntington diseasepor
dc.subjectOxidative stresspor
dc.subjectInsulin/IGF-1 signalingpor
dc.subjectNrf2por
dc.subjectMitochondriapor
dc.subjectReactive oxygen speciespor
dc.subjectStriatal cellspor
dc.subjectAktpor
dc.titleInsulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cellspor
dc.typearticlepor
degois.publication.firstPage129por
degois.publication.lastPage144por
degois.publication.titleFree Radical Biology and Medicinepor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0891584914002755por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.freeradbiomed.2014.06.023-
degois.publication.volume74por
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0001-6942-4328-
crisitem.author.orcid0000-0003-0700-3776-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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