Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27724
DC Field | Value | Language |
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dc.contributor.author | Morais, G. Ribeiro | - |
dc.contributor.author | Gano, L. | - |
dc.contributor.author | Kniess, T. | - |
dc.contributor.author | Bergmann, R. | - |
dc.contributor.author | Abrunhosa, A. | - |
dc.contributor.author | Santos, I. | - |
dc.contributor.author | Paulo, A. | - |
dc.date.accessioned | 2014-11-25T11:07:45Z | - |
dc.date.available | 2014-11-25T11:07:45Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | MORAIS, G. Ribeiro [et. al] - Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting. "Applied Radiation and Isotopes". ISSN 0969-8043. Vol. 82 (2013) p. 100-104 | por |
dc.identifier.issn | 0969-8043 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27724 | - |
dc.description.abstract | The formation of β-amyloid deposits is considered a histopathological feature of Alzheimer′s disease (AD). In vivo molecular imaging by means of amyloid-avid radiotracers will allow for an early and conclusive diagnostic of AD. Herein, we describe the radiosynthesis of the radiofluorinated styryl benzoxazole derivative [18F]-[2-[N-methyl-N-(2′-fluoroethyl)-4′-aminostyryl]benzoxazole] ([18F]-1) and its pre-clinical evaluation, including metabolic and biodistribution studies in male Wistar rats. The in vivo biological evaluation of [18F]-1 showed that this new radiotracer has a moderate brain uptake with a slow brain washout and a poor in vivo stability. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Alzheimer′s Disease | por |
dc.subject | β-Amyloid aggregation | por |
dc.subject | Molecular imaging | por |
dc.subject | Fluorine-18 | por |
dc.title | Radiosynthesis and in vivo evaluation of a 18F-labelled styryl-benzoxazole derivative for β-amyloid targeting | por |
dc.type | article | por |
degois.publication.firstPage | 100 | por |
degois.publication.lastPage | 104 | por |
degois.publication.title | Applied Radiation and Isotopes | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0969804313002923 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.apradiso.2013.07.003 | - |
degois.publication.volume | 82 | por |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.researchunit | ICNAS - Institute for Nuclear Sciences Applied to Health | - |
crisitem.author.orcid | 0000-0002-4145-854X | - |
Appears in Collections: | I&D CIBIT - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Radiosynthesis and in vivo.pdf | 580.99 kB | Adobe PDF | View/Open |
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