Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27677
DC Field | Value | Language |
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dc.contributor.author | Sousa-Ferreira, Lígia | - |
dc.contributor.author | Aveleira, Célia | - |
dc.contributor.author | Botelho, Mariana | - |
dc.contributor.author | Álvaro, Ana Rita | - |
dc.contributor.author | Almeida, Luís Pereira de | - |
dc.contributor.author | Cavadas, Cláudia | - |
dc.date.accessioned | 2014-11-19T11:55:02Z | - |
dc.date.available | 2014-11-19T11:55:02Z | - |
dc.date.issued | 2014-03-05 | - |
dc.identifier.citation | SOUSA-FERREIRA, Lígia [et. al] - Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro. "PLOS one". ISSN 1932-6203. Vol. 9 Nº. 3 (2014) p. e88917 | por |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27677 | - |
dc.description.abstract | A significant number of children undergo maternal exposure to antidepressants and they often present low birth weight. Therefore, it is important to understand how selective serotonin reuptake inhibitors (SSRIs) affect the development of the hypothalamus, the key center for metabolism regulation. In this study we investigated the proliferative actions of fluoxetine in fetal hypothalamic neuroprogenitor cells and demonstrate that fluoxetine induces the proliferation of these cells, as shown by increased neurospheres size and number of proliferative cells (Ki-67+ cells). Moreover, fluoxetine inhibits the differentiation of hypothalamic neuroprogenitor cells, as demonstrated by decreased number of mature neurons (Neu-N+ cells) and increased number of undifferentiated cells (SOX-2+ cells). Additionally, fluoxetine-induced proliferation and maintenance of hypothalamic neuroprogenitor cells leads to changes in the mRNA levels of appetite regulator neuropeptides, including Neuropeptide Y (NPY) and Cocaine-and-Amphetamine-Regulated-Transcript (CART). This study provides the first evidence that SSRIs affect the development of hypothalamic neuroprogenitor cells in vitro with consequent alterations on appetite neuropeptides. | por |
dc.language.iso | eng | por |
dc.publisher | PLOS | por |
dc.rights | openAccess | por |
dc.title | Fluoxetine Induces Proliferation and Inhibits Differentiation of Hypothalamic Neuroprogenitor Cells In Vitro | por |
dc.type | article | por |
degois.publication.firstPage | e88917 | por |
degois.publication.issue | 3 | por |
degois.publication.title | PLOS one | por |
dc.relation.publisherversion | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088917 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1371/journal.pone.0088917 | - |
degois.publication.volume | 9 | por |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CIBB - Center for Innovative Biomedicine and Biotechnology | - |
crisitem.author.orcid | 0000-0001-5831-3307 | - |
crisitem.author.orcid | 0000-0001-8020-9266 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Fluoxetine Induces Proliferation.pdf | 3.05 MB | Adobe PDF | View/Open |
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