Title: CA-125 AUC as a new prognostic factor for patients with ovarian cancer
Authors: Mano, Antonio 
Falcão, Amílcar 
Godinho, I. 
Santos, J. 
Leitão, F. 
Oliveira, C. 
Caramona, M. 
Keywords: neoplasias do ovario;prognostico;marcadores tumorais;farmacocinética;CA 125
Issue Date: May-2005
Publisher: Elsevier
Citation: Gynecologic Oncology 97:2 (2005) 529-534
Abstract: Abstract Objective The aim of the present study was to investigate the usefulness of the CA-125 area under the curve (AUC) as a new kinetic parameter for predicting overall survival in patients with ovarian cancer. In addition, the relationship of CA-125 AUC with other prognostic factors of ovarian cancer was evaluated. Methods Ninety-two patients that underwent primary line chemotherapy within 4 months after submission to cytoreductive surgery were included. For each patient, CA-125 AUC was calculated and a statistical analysis was conducted to compare CA-125 AUC behavior among patients according to several covariates. Results The mean age at diagnostic time was found to be 55.5 (16.1–82.4) years with a mean survival of 39.2 (3.5–100.1; SE = 2.6) months. Across FIGO stage I, II, III, and IV patients had a mean CA-125 AUC of 18.2, 24.6, 147.8, and 574.6 IU/ml*days, respectively (P < 0.05). At the evaluation date, living patients had a mean CA-125 AUC of 40.1 in contrast to 234.1 IU/ml*days (P < 0.05) for deceased ones. Patients with a complete response to primary chemotherapy had a mean CA-125 AUC of 48.8, while patients with a partial response had a mean of 251.7 IU/ml*days, and patients with no response or disease progression had a mean of 316.5 IU/ml*days (P < 0.05). The best CA-125 AUC performance is in predicting patient complete response to chemotherapy with a cut-off of 100 IU/ml*days and an accuracy of 82%. Conclusions Despite CA-125 AUC high correlation with the FIGO stage, residual disease, and patient final outcome, the main interest of CA-125 AUC calculation is to evaluate the treatment efficacy and to foresee a full chemotherapy response. Further studies should be carried out before extrapolating these results to other data sets.
Description: Prémio atribuído pelo International Research Promotion Council a Amílcar C. Falcão: Eminent Scientist of the Year 2006. Europe
URI: http://hdl.handle.net/10316/275
ISSN: 0090-8258
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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