Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27463
Title: Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids
Authors: Silva, Filomena
Figueiras, Ana
Gallardo, Eugenia
Nerín, Cristina
Domingues, Fernanda C.
Keywords: Stilbenes
Cyclodextrins
Bile salts
HPLC-DAD
Photostability
Inclusion complexes
Micelles
Issue Date: 15-Feb-2014
Publisher: Elsevier
Citation: SILVA, Filomena [et. al] - Strategies to improve the solubility and stability of stilbene antioxidants: a comparative study between cyclodextrins and bile acids. "Food Chemistry". ISSN 0308-8146. Vol. 145 (2014) p. 115-125
Abstract: Aiming at the development of an active food packaging, the goal of this study was to increase stilbenes (resveratrol (RV), pterostilbene (PT) and pinosylvin (PS)) aqueous solubility and stability using hydropropyl-cyclodextrins (HP-CDs) and bile salts. To evaluate stilbene concentration, an HPLC-DAD method was validated. Stilbene solubility was improved by the formation of inclusion complexes and micellar systems with higher solubility values obtained for the inclusion complexes with cyclodextrins. Inclusion complexes revealed a 1:1 stoichiometry for RV and PT and a 1:2 for PS. Solid state characterisation was carried out using X-ray diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry. 1H NMR studies were also performed to characterise the prepared complexes. Photostability studies revealed that CDs were able to increase stilbene photostability at 4 °C. This work showed that stable stilbene solutions can be achieved using hydroxypropyl-CDs, contributing for their incorporation in several materials for the food and pharmaceutical industries.
Peer review: Yes
URI: http://hdl.handle.net/10316/27463
DOI: 10.1016/j.foodchem.2013.08.034
ISSN: 0308-8146
Publisher Version: http://www.sciencedirect.com/science/article/pii/S0308814613011035
Appears in Collections:I&D CEFarmacêuticos - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat 
Strategies to improve the solubility and stability of stilbene antioxidants.pdf1.27 MBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.