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Title: Investigating herb–drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats
Authors: Rodrigues, Márcio 
Alves, Gilberto 
Falcão, Amílcar 
Keywords: Amiodarone; Citrus aurantium; Herb–drug interaction; Pharmacokinetics; Rats
Issue Date: Oct-2013
Publisher: Elsevier
Citation: RODRIGUES, Márcio; ALVES, Gilberto; FALCÃO, Amílcar - Investigating herb–drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics of amiodarone in rats. "Food and Chemical Toxicology". ISSN 0278-6915. Vol. 60 (2013) p. 153-159
Serial title, monograph or event: Food and Chemical Toxicology
Volume: 60
Abstract: Citrus aurantium extract has been largely used in weight loss and sports performance dietary supplements. However, the safety of C. aurantium-containing products has been questioned mainly due to the association of its use with adverse events in the cardiovascular system. Therefore, this work aimed to assess the potential for herb–drug interactions among a standardized C. aurantium extract (GMP certificate) and amiodarone (narrow therapeutic index drug) in rats. In a first pharmacokinetic study, rats were simultaneously co-administered with a single-dose of C. aurantium (164 mg/kg, p.o.) and amiodarone (50 mg/kg, p.o.); in a second study, rats were pre-treated during 14 days with C. aurantium (164 mg/kg/day, p.o.) and received amiodarone (50 mg/kg, p.o.) on the 15th day. Rats of the control groups received the corresponding volume of vehicle. Overall, after analysis of the pharmacokinetic data, it deserves to be highlighted the significant increase of the peak plasma concentration of amiodarone in rats pre-treated with C. aurantium extract, while the extent of systemic exposure was comparable between both groups. This paper reports, for the first time, data on the potential of herb–drug interaction between C. aurantium extract and amiodarone. However, specific clinical trials should be performed to confirm these results in humans.
ISSN: 0278-6915
DOI: 10.1016/j.fct.2013.07.041
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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