Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/27241
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dc.contributor.authorKamal, Ahmed-
dc.contributor.authorSuresh, Paidakula-
dc.contributor.authorRamaiah, M. Janaki-
dc.contributor.authorReddy, T. Srinivasa-
dc.contributor.authorKapavarapu, Ravi Kumar-
dc.contributor.authorRao, Bolla Narasimha-
dc.contributor.authorImthiajali, Syed-
dc.contributor.authorReddy, T. Lakshminarayan-
dc.contributor.authorPushpavalli, S. N. C. V. L.-
dc.contributor.authorShankaraiah, Nagula-
dc.contributor.authorPal-Bhadra, Manika-
dc.date.accessioned2014-10-13T14:49:12Z-
dc.date.available2014-10-13T14:49:12Z-
dc.date.issued2013-09-01-
dc.identifier.citationKAMAL, Ahmed [et. al] - 4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents. "Bioorganic & Medicinal Chemistry". ISSN 0968-0896. Vol. 21 Nº. 17 (2013) p. 5198-5208por
dc.identifier.issn0968-0896-
dc.identifier.urihttps://hdl.handle.net/10316/27241-
dc.description.abstractA series of 4β-[4′-(1-(aryl)ureido)benzamide]podophyllotoxin congeners (11a–l) were synthesized and evaluated for their cytotoxic activity against six human cancer cell lines. Some of the compounds like 11a, 11h, 11k and 11l showed significant anti-proliferative activity in Colo-205 cells and were superior to etoposide. The flow-cytometric analysis studies indicated that these compounds show strong G1 cell cycle arrest, as well exhibited improved inhibitory activities on DNA topoisomerase I and IIα enzymes. These compounds induce apoptosis by up regulating caspase-3 protein as observed by ELISA and Western blotting analysis. In addition, a brief structure–activity relationship studies within the series along with docking results of representative compounds 11a, 11h, 11k, 11l were presented.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectEtoposidepor
dc.subjectPodophyllotoxinpor
dc.subjectCell cyclepor
dc.subjectCytotoxicitypor
dc.subjectTopoisomerase-IIα enzymepor
dc.subjectTopoisomerase-I enzymepor
dc.title4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agentspor
dc.typearticlepor
degois.publication.firstPage5198por
degois.publication.lastPage5208por
degois.publication.issue17por
degois.publication.titleBioorganic & Medicinal Chemistrypor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0968089613005646por
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.bmc.2013.06.033-
degois.publication.volume21por
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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