Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/27241
DC Field | Value | Language |
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dc.contributor.author | Kamal, Ahmed | - |
dc.contributor.author | Suresh, Paidakula | - |
dc.contributor.author | Ramaiah, M. Janaki | - |
dc.contributor.author | Reddy, T. Srinivasa | - |
dc.contributor.author | Kapavarapu, Ravi Kumar | - |
dc.contributor.author | Rao, Bolla Narasimha | - |
dc.contributor.author | Imthiajali, Syed | - |
dc.contributor.author | Reddy, T. Lakshminarayan | - |
dc.contributor.author | Pushpavalli, S. N. C. V. L. | - |
dc.contributor.author | Shankaraiah, Nagula | - |
dc.contributor.author | Pal-Bhadra, Manika | - |
dc.date.accessioned | 2014-10-13T14:49:12Z | - |
dc.date.available | 2014-10-13T14:49:12Z | - |
dc.date.issued | 2013-09-01 | - |
dc.identifier.citation | KAMAL, Ahmed [et. al] - 4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents. "Bioorganic & Medicinal Chemistry". ISSN 0968-0896. Vol. 21 Nº. 17 (2013) p. 5198-5208 | por |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://hdl.handle.net/10316/27241 | - |
dc.description.abstract | A series of 4β-[4′-(1-(aryl)ureido)benzamide]podophyllotoxin congeners (11a–l) were synthesized and evaluated for their cytotoxic activity against six human cancer cell lines. Some of the compounds like 11a, 11h, 11k and 11l showed significant anti-proliferative activity in Colo-205 cells and were superior to etoposide. The flow-cytometric analysis studies indicated that these compounds show strong G1 cell cycle arrest, as well exhibited improved inhibitory activities on DNA topoisomerase I and IIα enzymes. These compounds induce apoptosis by up regulating caspase-3 protein as observed by ELISA and Western blotting analysis. In addition, a brief structure–activity relationship studies within the series along with docking results of representative compounds 11a, 11h, 11k, 11l were presented. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Etoposide | por |
dc.subject | Podophyllotoxin | por |
dc.subject | Cell cycle | por |
dc.subject | Cytotoxicity | por |
dc.subject | Topoisomerase-IIα enzyme | por |
dc.subject | Topoisomerase-I enzyme | por |
dc.title | 4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents | por |
dc.type | article | por |
degois.publication.firstPage | 5198 | por |
degois.publication.lastPage | 5208 | por |
degois.publication.issue | 17 | por |
degois.publication.title | Bioorganic & Medicinal Chemistry | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0968089613005646 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.bmc.2013.06.033 | - |
degois.publication.volume | 21 | por |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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4β-[4’-(1-(Aryl)ureido)benzamide]podophyllotoxins.pdf | 1.42 MB | Adobe PDF | View/Open |
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