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Title: Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection
Authors: Santos-Carvalho, Ana 
Álvaro, Ana Rita 
Martins, João 
Ambrósio, António Francisco 
Cavadas, Cláudia 
Keywords: Neuropeptide Y; NPY receptors; Retina; Retinal neural cells; Neuroprotection; Neuromodulation
Issue Date: Jan-2014
Publisher: Elsevier
Citation: SANTOS-CARVALHO, Ana [et al.] - Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection. "Progress in Neurobiology". ISSN 0301-0082. Vol. 112 (2014) p. 70-79
Serial title, monograph or event: Progress in Neurobiology
Volume: 112
Abstract: Neuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the distribution of NPY receptors in the retina are still scarce. Although the physiological roles of NPY in the retina have not been completely elucidated, its early expression strongly suggests that NPY may be involved in the development of retinal circuitry. NPY inhibits the increase in [Ca2+]i triggered by elevated KCl in retinal neurons, protects retinal neural cells against toxic insults and induces the proliferation of retinal progenitor cells. In this review, we will focus on the roles of NPY in the retina, specifically proliferation, neuromodulation and neuroprotection. Alterations in the NPY system in the retina might contribute to the pathogenesis of retinal degenerative diseases, such as diabetic retinopathy and glaucoma, and NPY and its receptors might be viewed as potentially novel therapeutic targets.
ISSN: 0301-0082
DOI: 10.1016/j.pneurobio.2013.10.002
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D IBILI - Artigos em Revistas Internacionais

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