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Title: Molecular mechanisms beyond glucose transport in diabetes-related male infertility
Authors: Alves, M. G. 
Martins, A. D. 
Rato, L. 
Moreira, P. I. 
Socorro, S. 
Oliveira, P. F. 
Keywords: Diabetes; Insulin; Male infertility; Oxidative stress; Testicular metabolism
Issue Date: May-2013
Publisher: Elsevier
Citation: ALVES, M. G. [et al.] - Molecular mechanisms beyond glucose transport in diabetes-related male infertility. "Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease". ISSN 0925-4439. Vol. 1832 Nº. 5 (2013) p. 626-635
Serial title, monograph or event: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume: 1832
Issue: 5
Abstract: Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. The increasing incidence of DM worldwide will inevitably result in a higher prevalence of this pathology in men of reproductive age and subfertility or infertility associated with DM is expected to dramatically rise in upcoming years. From a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (DNA) integrity, are often studied due to their direct implications in natural and assisted conception. Nevertheless, recent studies based on the molecular mechanisms beyond glucose transport in testicular cells provide new insights in DM-induced alterations in male reproductive health. Testicular cells have their own glucose sensing machinery that react to hormonal fluctuations and have several mechanisms to counteract hyper- and hypoglycemic events. Moreover, the metabolic cooperation between testicular cells is crucial for normal spermatogenesis. Sertoli cells (SCs), which are the main components of blood–testis barrier, are not only responsible for the physical support of germ cells but also for lactate production that is then metabolized by the developing germ cells. Any alteration in this tied metabolic cooperation may have a dramatic consequence in male fertility potential. Therefore, we present an overview of the clinical significance of DM in the male reproductive health with emphasis on the molecular mechanisms beyond glucose fluctuation and transport in testicular cells.
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2013.01.011
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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