Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/26909
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rao, V. Mallikarjuna | - |
dc.contributor.author | Kumar, P. Mahesh | - |
dc.contributor.author | Rambabu, D. | - |
dc.contributor.author | Kapavarapu, Ravikumar | - |
dc.contributor.author | Rani, S. Shobha | - |
dc.contributor.author | Misra, Parimal | - |
dc.contributor.author | Pal, Manojit | - |
dc.date.accessioned | 2014-09-24T09:50:28Z | - |
dc.date.available | 2014-09-24T09:50:28Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | RAO, V. Mallikarjuna [et al.] - Novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives as potential inhibitors of chorismate mutase. "Bioorganic Chemistry". ISSN 0045-2068. Vol. 51 (2013) p. 48-53 | por |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://hdl.handle.net/10316/26909 | - |
dc.description.abstract | A series of novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one (DHPM) derivatives were designed, synthesized and evaluated in vitro as potential inhibitors of chorismate mutase (CM). All these compounds were prepared via a multi-component reaction (MCR) involving sequential I2-mediated Biginelli reaction followed by Cu-free Sonogashira coupling. Some of them showed promising inhibitory activities when tested at 30 μM. One compound showed dose dependent inhibition of CM with IC50 value of 14.76 ± 0.54 μM indicating o-alkynylphenyl substituted DHPM as a new scaffold for the discovery of promising inhibitors of CM. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.rights | openAccess | por |
dc.subject | Pyrimidinone | por |
dc.subject | Alkyne | por |
dc.subject | Iodine | por |
dc.subject | Palladium | por |
dc.subject | Chorismate mutase | por |
dc.title | Novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives as potential inhibitors of chorismate mutase | por |
dc.type | article | por |
degois.publication.firstPage | 48 | por |
degois.publication.lastPage | 53 | por |
degois.publication.title | Bioorganic Chemistry | por |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0045206813000540 | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1016/j.bioorg.2013.08.002 | - |
degois.publication.volume | 51 | por |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Novel alkynyl substituted 3,4-dihydropyrimidin-2(1H)-one derivatives as potential inhibitors.pdf | 800.21 kB | Adobe PDF | View/Open |
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