Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/23325
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dc.contributor.authorCunha-Oliveira, Teresa-
dc.contributor.authorSilva, Lisbeth-
dc.contributor.authorSilva, Ana Maria-
dc.contributor.authorMoreno, António J.-
dc.contributor.authorOliveira, Catarina R.-
dc.contributor.authorSantos, Maria S.-
dc.date.accessioned2013-05-01T10:26:57Z-
dc.date.available2013-05-01T10:26:57Z-
dc.date.issued2013-05-01-
dc.identifier.urihttp://hdl.handle.net/10316/23325-
dc.description.abstractMitochondrial function and energy metabolism are affected in brains of human cocaine abusers. Cocaine is known to induce mitochondrial dysfunction in cardiac and hepatic tissues, but its effects on brain bioenergetics are less documented. Furthermore, the combination of cocaine and opioids (speedball) was also shown to induce mitochondrial dysfunction. In this work, we compared the effects of cocaine and/or morphine on the bioenergetics of isolated brain and liver mitochondria, to understand their specific effects in each tissue. Upon energization with complex I substrates, cocaine decreased state-3 respiration in brain (but not in liver) mitochondria and decreased uncoupled respiration and mitochondrial potential in both tissues, through a direct effect on complex I. Morphine presented only slight effects on brain and liver mitochondria, and the combination cocaine+morphine had similar effects to cocaine alone, except for a greater decrease in state-3 respiration. Brain and liver mitochondrial respirations were differentially affected, and liver mitochondria were more prone to proton leak caused by the drugs or their combination. This was possibly related with a different dependence on complex I in mitochondrial populations from these tissues. In summary, cocaine and cocaine+morphine induce mitochondrial complex I dysfunction in isolated brain and liver mitochondria, with specific effects in each tissue.por
dc.language.isoengpor
dc.rightsopenAccesspor
dc.subjectspeedballpor
dc.subjectmitochondriapor
dc.titleMitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondriapor
dc.typearticlepor
degois.publication.firstPage298por
degois.publication.lastPage306por
degois.publication.titleToxicology Letterspor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378427413001392por
dc.peerreviewedYespor
degois.publication.volume219por
uc.controloAutoridadeSim-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptCNC - Center for Neuroscience and Cell Biology-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.deptFaculty of Medicine-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitMARE - Marine and Environmental Sciences Centre-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0002-7382-0339-
crisitem.author.orcid0000-0001-7172-4266-
crisitem.author.orcid0000-0003-3575-7604-
crisitem.author.orcid0000-0001-6942-4328-
crisitem.author.orcid0000-0002-6881-9392-
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
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