Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/21650
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dc.contributor.authorNatu, Mădălina V.-
dc.contributor.authorGaspar, Manuel N.-
dc.contributor.authorRibeiro, Carlos A. Fontes-
dc.contributor.authorCabrita, António M.-
dc.contributor.authorSousa, Hermínio C. de-
dc.contributor.authorGil, M. H.-
dc.date.accessioned2013-02-14T16:21:49Z-
dc.date.issued2011-07-
dc.identifier.citationNATU, Mădălina V. [et al.] - In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment. "International Journal of Pharmaceutics". ISSN 0378-5173. 415:1–2 (2011) 73-82por
dc.identifier.issn0378-5173-
dc.identifier.urihttp://hdl.handle.net/10316/21650-
dc.description.abstractImplantable disks for glaucoma treatment were prepared by blending poly(ɛ-caprolactone), PCL, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) and dorzolamide. Their in vivo performance was assessed by their capacity to decrease intraocular pressure (IOP) in normotensive and hypertensive eyes. Drug mapping showed that release was complete from blend disks and the low molecular weight (MW) PCL after 1 month in vivo. The high MW PCL showed non-cumulative release rates above the therapeutic level during 3 months in vitro. In vivo, the fibrous capsule formation around the implant controls the drug release, working as a barrier membrane. Histologic analysis showed normal foreign body reaction response to the implants. In normotensive eyes, a 20% decrease in IOP obtained with the disks during 1 month was similar to Trusopt® eyedrops treatment. In hypertensive eyes, the most sustained decrease was shown by the high MW PCL (40% after 1 month, 30% after 2 months). It was shown that the implants can lower IOP in sustained manner in a rabbit glaucoma model.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsopenAccesspor
dc.subjectPoly(ɛ-caprolactone)por
dc.subjectSubconjunctival implantpor
dc.subjectControlled drug releasepor
dc.subjectIn vivopor
dc.subjectIntraocular pressurepor
dc.subjectGlaucomapor
dc.titleIn vitro and in vivo evaluation of an intraocular implant for glaucoma treatmentpor
dc.typearticlepor
degois.publication.firstPage73por
degois.publication.lastPage82por
degois.publication.issue1-2por
degois.publication.titleInternational Journal of Pharmaceuticspor
dc.relation.publisherversionwww.sciencedirect.com/science/article/pii/S0378517311004789dxpor
dc.peerreviewedYespor
dc.identifier.doi10.1016/j.ijpharm.2011.05.047-
degois.publication.volume415por
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Sciences and Technology-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.parentdeptUniversity of Coimbra-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.researchunitCIEPQPF – Chemical Process Engineering and Forest Products Research Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0002-9707-4895-
crisitem.author.orcid0000-0001-5165-5849-
crisitem.author.orcid0000-0002-2629-7805-
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais
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