Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/20224
Title: A intervenção da célula epitelial na asma
Other Titles: The role of the epithelial cell in asthma
Authors: Mota-Pinto, Anabela 
Todo-Bom, Ana 
Keywords: Asma; Célula epitelial
Issue Date: 2009
Serial title, monograph or event: Revista Portuguesa de Pneumologia
Volume: 15
Issue: 3
Abstract: Faz -se uma revisão da intervenção da célula epitelial brônquica na fisiopatologia da asma. O epitélio que reveste as vias respiratórias actua como uma barreira física, separando o meio externo do meio interno pulmonar, controla a permeabilidade intercelular e transcelular, e, deste modo, a acessibilidade dos agressores inalantes às células apresentadoras de antigénio envolvidas na resposta imunoinflamatória. As células epiteliais unidas por tight junctions contribuem para a integridade das vias aéreas e expressam poliovirus receptor–related protein (PRR), toll like receptors (TLR) e protease -activated receptors (PAR), que reconhecem agentes bacterianos e alergénios. A sua disfunção transforma-as em fonte de mediadores intervenientes na inflamação. Abstract It is done a review of the intervention of the epithelial bronchial cell in the pathophysiology of asthma. The respiratory epithelium acts as a physical barrier that separates the external environment from the pulmonary internal environment. It controls the intercellular and trans -cellular permeability and this way the accessibility of the inhaled pathogens to the antigen presenting cells involved in the immuno-inflammatory response. Epithelial cells connected by tight junctions contribute to the barrier function of the airways. They express a poliovirus receiver – related protein (PRR), toll like receptors (TLRs) and protease-activated receptors (PARs), which recognize bacterial agents and allergens. Its dysfunction turns them into important sources of inflammatory mediators.
URI: http://hdl.handle.net/10316/20224
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Nacionais

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