Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/18513
DC Field | Value | Language |
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dc.contributor.author | Oliveira, M. Teresa | - |
dc.contributor.author | Rego, A. Cristina | - |
dc.contributor.author | Morgadinho, M. Teresa | - |
dc.contributor.author | Macedo, Tice R. | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.date.accessioned | 2012-03-08T18:32:56Z | - |
dc.date.available | 2012-03-08T18:32:56Z | - |
dc.date.issued | 2012-03-08 | - |
dc.identifier.uri | https://hdl.handle.net/10316/18513 | - |
dc.description.abstract | Cell death and reactive oxygen species production have been suggested to be involved in neurodegeneration induced by the drugs of abuse. In this study we analyze the toxicity of the following drugs of abuse: heroin, morphine, d-amphetamine, and cocaine in undifferentiated PC12 cells, used as dopaminergic neuronal models. Our data show that opioid drugs (heroin and morphine) are more toxic than stimulant drugs (d-amphetamine and cocaine). Toxic effects induced by heroin are associated with a decrease in intracellular dopamine, an increase in DOPAC levels, and the formation of ROS, whereas toxic effects induced by amphetamine are associated with a decrease in intracellular dopamine and in ATP/ADP levels. In contrast with cocaine, both amphetamine and heroin induced features of apoptosis. The data suggest that the death of cultured PC12 cells induced by the drugs of abuse is correlated with a decrease in intracellular dopamine levels, which can be associated with an increased dopamine turnover and oxidative cell injury. | por |
dc.language.iso | por | por |
dc.rights | openAccess | por |
dc.title | Toxic Effects of Opioid and Stimulant Drugs on Undifferentiated PC12 Cells | por |
dc.type | article | por |
degois.publication.firstPage | 487 | por |
degois.publication.lastPage | 496 | por |
degois.publication.title | Annals of the New York Academy of Sciences | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2002.tb04190.x/abstract | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1111/j.1749-6632.2002.tb04190.x | - |
degois.publication.volume | 965 | por |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | pt | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-0700-3776 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Oliveira et al. - 2002 - Annals of the New York Academy of Sciences.pdf | 3.47 MB | Adobe PDF | View/Open |
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