Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/18512
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oliveira, M. Teresa | - |
dc.contributor.author | Rego, A. Cristina | - |
dc.contributor.author | Macedo, Tice R. | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.date.accessioned | 2012-03-08T18:27:43Z | - |
dc.date.available | 2012-03-08T18:27:43Z | - |
dc.date.issued | 2012-03-08 | - |
dc.identifier.uri | https://hdl.handle.net/10316/18512 | - |
dc.description.abstract | Drugs of abuse induce the release of dopamine in the central nervous system, particularly in the mesolimbic-mesocortical pathway. As dopamine may act as a neurotoxin, in this study, we analyzed the effects of the drugs of abuse, cocaine, heroin, and amphetamine, on the neurodegeneration of PC12 cells, a dopaminergic cell line, by evaluating the activity of caspase-3 and mitochondrial cytochrome c release. All the drugs were shown to induce caspase-3 activation, similarly to staurosporine, a classical inducer of apoptotic cell death. Furthermore, like staurosporine, the drugs of abuse induced a decrease in mitochondrial cytochrome c content, suggesting the involvement of the mitochondrial apoptotic pathway. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.title | Drugs of abuse induce apoptotic features in PC12 cells. | por |
dc.type | article | por |
degois.publication.firstPage | 667 | por |
degois.publication.lastPage | 670 | por |
degois.publication.title | Annals of the New York Academy of Sciences | por |
dc.peerreviewed | Yes | por |
dc.identifier.doi | 10.1196/annals.1299.121 | - |
degois.publication.volume | 1010 | por |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0003-0700-3776 | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Oliveira et al. - 2003 - Annals of the New York Academy of Sciences.pdf | 2.04 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
55
checked on May 20, 2024
WEB OF SCIENCETM
Citations
5
48
checked on May 2, 2024
Page view(s) 20
758
checked on May 28, 2024
Download(s)
371
checked on May 28, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.