Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12885
DC Field | Value | Language |
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dc.contributor.author | Santos, Rita C. | - |
dc.contributor.author | Salvador, Jorge A. R. | - |
dc.contributor.author | Marín, Silvia | - |
dc.contributor.author | Cascante, Marta | - |
dc.date.accessioned | 2010-03-12T14:16:39Z | - |
dc.date.available | 2010-03-12T14:16:39Z | - |
dc.date.issued | 2009-09-01 | - |
dc.identifier.citation | Bioorganic & Medicinal Chemistry. 17:17 (2009) 6241-6250 | en_US |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | https://hdl.handle.net/10316/12885 | - |
dc.description.abstract | A series of new imidazole carboxylic esters (carbamates) and N-acylimidazole derivatives of betulin and betulinic acid (14-29) have been synthesized. The new compounds were screened for in vitro cytotoxicity activity against human cancer cell lines HepG2, Jurkat and HeLa. A number of compounds have shown IC50 values lower than 2 [mu]M against the cancer cell lines tested and the vast majority has shown a better cytotoxicity profile than betulinic acid, including the betulin derivatives. N-Acylimidazole derivatives 26 and 27 (IC50 0.8 and 1.7 [mu]M in HepG2 cells) and the C-3 carbamate derivative 16 (IC50 2.0 [mu]M in HepG2 cells) were the most promising compounds. Based on the observed cytotoxicity, structure-activity relationships have been established | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd. | en_US |
dc.rights | openAccess | en_US |
dc.subject | Triterpenoids | en_US |
dc.subject | Betulinic acid | en_US |
dc.subject | Imidazole | en_US |
dc.subject | Cytotoxicity | en_US |
dc.title | Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.bmc.2009.07.050 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
crisitem.author.orcid | 0000-0003-0779-6083 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Novel semisynthetic derivatives.pdf | 903.12 kB | Adobe PDF | View/Open |
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