Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12666
DC Field | Value | Language |
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dc.contributor.author | Ribeiro, Laura | - |
dc.contributor.author | Loftsson, Thorsteinn | - |
dc.contributor.author | Ferreira, Domingos | - |
dc.contributor.author | Veiga, Francisco | - |
dc.date.accessioned | 2010-03-03T14:54:18Z | - |
dc.date.available | 2010-03-03T14:54:18Z | - |
dc.date.issued | 2003-08 | - |
dc.identifier.citation | Chemical & Pharmaceutical Bulletin. 51:8 (2003) 914-922 | en_US |
dc.identifier.issn | 0009-2363 | - |
dc.identifier.uri | https://hdl.handle.net/10316/12666 | - |
dc.description.abstract | The purpose of this study was to investigate the interactions between vinpocetine (VP), sulfobutyl ether beta-cyclodextrin (SBEbetaCD) and the water-soluble polymers polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC). The water-soluble polymers were shown to improve the complexation efficiency of SBEbetaCD, and thus less SBEbetaCD was needed to prepare solid VP-SBEbetaCD complexes in the presence of the polymers. The interactions between VP and SBEbetaCD, with or without PVP or HPMC, were thoroughly investigated in aqueous solutions using the phase-solubility method as well as in the solid state. The amount of VP solubilized in water or aqueous polymer solution increased linearly with increasing SBEbetaCD concentration, demonstrating A(L)-type plots. We estimated the apparent stability constant (K(c)) at room temperature of VP-SBEbetaCD binary complex to be 340 M(-1) and this value increased to 490 M(-1) or 390 M(-1), respectively, with the addition of PVP and HPMC, assuming a 1 : 1 VP-SBEbetaCD molar ratio. Improvement in the K(c) values for ternary complexes clearly confirmed the benefit of the addition of water-soluble polymers to promote higher complexation efficiency. Solid VP-SBEbetaCD binary and ternary systems were prepared by physical mixing, kneading, coevaporation, and lyophilization methods and fully characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray diffractometry. The results obtained suggest that coevaporation and lyophilization methods yield a higher degree of amorphous entities and indicated formation of VP-SBEbetaCD binary and ternary complexes | en_US |
dc.language.iso | eng | en_US |
dc.publisher | The Pharmaceutical Society of Japan | en_US |
dc.rights | openAccess | en_US |
dc.subject | Sulfobutyl ether b -cyclodextrin | en_US |
dc.subject | Vinpocetine | en_US |
dc.subject | Water-soluble polymer | en_US |
dc.subject | Solubility study | en_US |
dc.subject | Complexation efficiency | en_US |
dc.subject | Characterization | en_US |
dc.title | Investigation and physicochemical characterization of vinpocetine-sulfobutyl ether beta-cyclodextrin binary and ternary complexes | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1248/cpb.51.914 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-1041-0068 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Investigation and physicochemical characterization of vinpocetine-sulfobutyl ether.pdf | 411.5 kB | Adobe PDF | View/Open |
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